Carbohydrates as Polyfunctional Scaffolds in Combinatorial Synthesis

Abstract

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Carbohydrate-Based Scaffolds in Drug Discovery

“…The six building blocks (12)(13)(14)(15)(16)(17) shown below utilize a -Dglucose or a -D-galactose core from which a hydroxy group, a carboxylic acid and an amine, the latter masked as an azide, function as attachment points for the chosen pharmacophores. …”

“…Following the first publication describing the successful use of carbohydrates as new scaffolds in the area of peptidomimetics [1], there has been a growing interest in this field and certain aspects have recently been reviewed; ranging from combinatorial oligosaccharide and glycopeptide synthesis [2][3][4][5][6][7] or the use of sugar amino acids [5,8] in peptide chemistry to the development [9] and use of carbohydrate scaffolds to mimic bioactive molecules [10][11][12][13][14]. The present review aims to provide an overview of drug discovery approaches that have utilized carbohydrates as scaffolds to display chemical functionalities, which have the potential to interact with a receptor or enzyme.…”