Findings suggest that positive psychological variables play a significant role in postrehabilitation subjective well-being for persons with spinal cord injury and may provide potential avenues for interventions to facilitate positive outcomes.

Background There is limited research on factors that influence the rate of progression in Alzheimer’s Disease (AD). A history of traumatic brain injury (TBI) is associated with an increased risk for AD, but its role on the rate of dementia progression after the onset of AD has not been examined. Method A population-based cohort of 325 persons with incident AD were followed for up to 11 years. The sample was 65% female with mean (sd) age of dementia onset = 84.4 (6.4) years. History of TBI was categorized as: number, severity (with or without loss of consciousness), and timing in relation to dementia onset (within 10 years or more than 10 years). Cognition was assessed by the Consortium to Establish a Registry of AD (CERAD) battery and functional ability was assessed by the Clinical Dementia Rating Sum of Boxes (CDR-sb). Results In linear mixed models, a history of TBI within 10 years of onset showed faster progression of functional impairment (LR x2 = 10.27, p = 0.006), while those with TBI more than 10 years before dementia onset had higher scores on a measure of list learning (β = 1.61, p = 0.003) and semantic memory (β = 0.75, p = 0.0035). Conclusion History of TBI and its recency may be a useful factor to predict functional progression in the course of AD.

No abstract

No abstract

No abstract