The association of traumatic brain injury with rate of progression of cognitive and functional impairment in a population-based cohort of Alzheimer's disease: the Cache County Dementia Progression Study

Gilbert, Mac; Snyder, Christine; Corcoran, Chris; Norton, Maria C.; Tschanz, Jo Ann T.

doi:10.1017/s1041610214000842

Cited by 36 publications

(20 citation statements)

References 34 publications

(46 reference statements)

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“…However, a recent report utilizing a large (N = 51,799) TBI sample reported that a mild or moderate-to-severe TBI was associated with a higher risk for dementia, even after adjusting for several demographic, medical, and psychiatric factors [10]. In addition, TBI occurring later in life (i.e., within 10 years of AD onset), has been found to be related to higher risk estimates and more rapid decline after dementia onset [19]. Yet another related issue is that of repetitive TBI in relation to risk for cognitive decline later in life.…”

Section: Discussionmentioning

confidence: 99%

“…While previous research has emphasized the relationship between a history of TBI and AD [6,19,20], little is known about the potential impact of TBI on the development of MCI. For example, Guskiewicz et al (2005) reported a relationship between MCI symptoms and a history of three or more concussions in a small sample of retired athletes [21].…”

Section: Introductionmentioning

confidence: 99%

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Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

LoBue

Denney

Hynan

et al. 2016

JAD

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This study examined whether history of traumatic brain injury (TBI) is associated with increased risk and earlier onset of mild cognitive impairment (MCI). Subjects with MCI (n =3,187) and normal cognition (n=3,244) were obtained from the National Alzheimer's Coordinating Center database. TBI was categorized based on lifetime reported TBI with loss of consciousness (LOC) without chronic deficit. Logistic regression was used to examine TBI history as a predictor of MCI, adjusted for demographics, apolipoprotein E-e4 (Apoe4), a composite vascular risk score, and history of psychiatric factors. ANCOVA was used to examine whether age at MCI diagnosis and estimated age of onset differed between those with (TBI+) and without (TBI-) a history of TBI. TBI history was a significant predictor (p<.01) and associated with increased odds of MCI diagnosis in unadjusted (OR=1.25; 95% CI =1.05 – 1.49) and adjusted models, accounting for age, education, Apoe4, and a composite vascular score (OR=1.32; 95% CI=1.10 – 1.58). This association, however, was largely attenuated (OR=1.14; 95% CI=0.94 – 1.37; p=.18) after adjustment for reported history of depression. MCI was diagnosed a mean of 2.3 years earlier (p<.001) in the TBI+ group, and although TBI+ subjects had an estimated mean of decline 1.7 years earlier, clinician-estimated age of onset failed to differ (p =.13) when sex and psychiatric factors were controlled. This is the first report of a possible role for TBI as a risk factor in MCI, but its association may be related to other factors such as sex and depression and requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

LoBue

Denney

Hynan

et al. 2016

JAD

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“…Aβ levels are altered in cerebro-spinal and interstitial cerebral fluid in patients with TBI (Magnoni and Brody, 2010 ; Tsitsopoulos and Marklund, 2013 ) and correlate with clinical outcome (Magnoni and Brody, 2010 ). A history of TBI prior to the onset of dementia correlates with greater amyloid burden in patients with mild cognitive deficits (Mielke et al, 2014 ) and is associated with faster rates of cognitive decline in AD patients (Moretti et al, 2012 ; Gilbert et al, 2014 ). In TBI patients, APP transcription is upregulated and its axonal transport is interrupted due to diffuse axonal injury, which results in deposition of APP and its products in axonal “bulbs” (Hayashi et al, 2015 ).…”

Section: Traumatic Brain Injury App and Admentioning

confidence: 99%

APP as a Protective Factor in Acute Neuronal Insults

Hefter

Draguhn

2017

Front. Mol. Neurosci.

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Despite its key role in the molecular pathology of Alzheimer’s disease (AD), the physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence, however, points towards a neuroprotective role of this membrane protein in situations of metabolic stress. A key observation is the up-regulation of APP following acute (stroke, cardiac arrest) or chronic (cerebrovascular disease) hypoxic-ischemic conditions. While this mechanism may increase the risk or severity of AD, APP by itself or its soluble extracellular fragment APPsα can promote neuronal survival. Indeed, different animal models of acute hypoxia-ischemia, traumatic brain injury (TBI) and excitotoxicity have revealed protective effects of APP or APPsα. The underlying mechanisms involve APP-mediated regulation of calcium homeostasis via NMDA receptors (NMDAR), voltage-gated calcium channels (VGCC) or internal calcium stores. In addition, APP affects the expression of survival- or apoptosis-related genes as well as neurotrophic factors. In this review, we summarize the current understanding of the neuroprotective role of APP and APPsα and possible implications for future research and new therapeutic strategies.

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“…Individuals who experience multiple concussions or sustain a single moderate to severe-TBI have a two-to fourfold increased risk of developing subsequent neurodegenerative diseases [5]. Furthermore, a history of TBI within 10 years of an ADRD diagnosis is associated with more rapid functional impairment progression [6].…”

Section: Introductionmentioning

confidence: 99%

Supporting caregivers of veterans with Alzheimer’s disease and traumatic brain injury: study protocol for a randomized controlled trial

Carnahan

Judge

Daggy

et al. 2020

Trials

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Background: Patients with Alzheimer's disease and related dementias (ADRD) and traumatic brain injury (TBI) and their caregivers require cognitive and behavioral symptom management, interdisciplinary care, support for caregivers, and seamless care coordination between providers. Caring for someone with ADRD or TBI is associated with higher rates of psychological morbidity and burden, social isolation, financial hardship, and deterioration of physical health. Tremendous need exists for primary care-based interventions that concurrently address the care needs of dyads and aim to improve care and outcomes for both individuals with ADRD and TBI and their family caregivers. Methods: The Aging Brain Care Acquiring New Skills While Enhancing Remaining Strengths (ABC ANSWERS) study is a randomized controlled trial that tests the effectiveness of an intervention based on two evidence-based programs that have been developed for and previously tested in populations with ADRD, TBI, stroke, and late-life depression and/or who have survived an intensive care unit stay. This study includes 200 dyads comprised of a veteran with a diagnosis of ADRD or TBI and the veteran's primary informal caregiver. Dyads are randomized to receive the ABC ANSWERS intervention or routine Veterans Health Administration (VHA) primary care with a standardized educational and resource information packet. Data collection occurs at baseline and three follow-up time points (3 months, 6 months, and 12 months). The primary outcome is caregiver quality of life (QoL). A secondary measure for the caregiver is caregiver burden. Secondary measures for both the veteran and caregiver include symptoms of depression and anxiety. Discussion: The ABC ANSWERS intervention integrates common features of an evidence-based collaborative care model for brain health while concurrently attending to the implementation barriers of delivering care and skills to dyads. We hypothesize that caregivers in dyads randomized to the ABC ANSWERS program will experience higher levels of QoL and lower levels of depression, anxiety, dyadic strain, and caregiver burden at 12 months than those receiving usual VHA primary care.

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The association of traumatic brain injury with rate of progression of cognitive and functional impairment in a population-based cohort of Alzheimer's disease: the Cache County Dementia Progression Study

Cited by 36 publications

References 34 publications

Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

APP as a Protective Factor in Acute Neuronal Insults

Supporting caregivers of veterans with Alzheimer’s disease and traumatic brain injury: study protocol for a randomized controlled trial

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