The involvement of intestinal flora endotoxin (ET) in the regulation of immune homeostasis, namely, the maintenance of the physiological tone of all components of the immune system (so-called systemic endotoxinemia, SEE) is postulated. Excessive endotoxin in the systemic blood flow under conditions of the failure of endotoxin-binding and endotoxin-eliminating systems results in another phenomenon, endotoxin aggression (EA), which is regarded as a common factor of pathogenesis of various human diseases. An important role of endotoxin insufficiency in the development of immunodeficiencies is hypothesized.
To the blessed memory of my teacher Donat Semenovich Sarkisov
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.