The role of the kidneys in endotoxin aggression (EA) and the involvement of EA in disturbance of hemostasis were shown in 33 children with congenital urological pathology. With a progressive decrease in the accumulative-excretory function of the kidneys, compensated chronic EA became subcompensated or noncompensated with a pronounced clinical manifestation: fever, exacerbation of chronic pyelonephritis, an expanded form of the disseminated intravascular coagulation (DIC) III syndrome, and macrohematuria. Preoperative correction of antiendotoxin immunity and hemostasis and improvement of urine passage prevented bleeding and other postoperative complications. T 2 Ao T 3 T A 1 Am FA T 1 Diagram of a normal electrocoagulogram. See Methods for abbreviations.
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