Lymphocytotoxicity against tumour-specific antigens has been examined using cultures of 11 ncwroblastomas and I I Wilms' tumours. The reactivity of lymphocytes from patients with neuroblastomas, Wilm's tumour, other tumours and from normal individuals was examined. Iir both systems tumour-specific lymphocytotoxicity was demonstrated in both autochthonous and allogeneic combinations. Cross-reactivity wus observed between Wilms' tumour and hypernephromu but not with respcct to other tumours,
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