Cell‐mediated immunity and blocking factors in patients with tumours of the central nervous system

Antigens in human glioblastomas and meningiomas: search for tumour and onco-foetal antigens. Estimation of S-100 and GFA protein

“…Also, cellular immune reactions have indicated the existence of human tumourassociated antigens (Brooks et al, 1972;Levy et al, 1972;Kumar et al, 1973;Oda, 1974). In these studies the chemical nature of the antigens was not investigated, but they are usually presumed to be membrane proteins.…”

Detection of IgG on glioblastoma cell surfacein vivo

“…It is not clear as to whether the IgG distributed on the surface of tumour cells acts to suppress or accelerate cellular immunity and complement-dependent cytolysis of tumovr cells in vivo. Ilfformation is now accumulating to h~dicate that the cell-mediated immune responses against tumour cells may be significantly modified by the sera of patients with primary i~tra-cranial tumours (Kumar et al 1973, Brooks et al 1974, Young et al 1976). …”

Therapeutic approach to the management of HER2-positive breast cancer metastatic to the brain

“…BBB is compromised in the microvasculature associated with tumours and indeed also in metastatic lesions of systemic primary tumours. It has been shown beyond reasonable doubt that the barrier properties as defined by immunological and pharmacological reactivity are breached in both primary and secondary tumours [18]. It should be noted here however that brain tumours do not normally metastasise to extracranial sites and iatrogenic factors might account for instances where brain tumours seemed to have formed metastases.…”