The antibacterial activity of cefotetan, 8 other beta‐lactam antibiotics and gentamicin, was tested in vitro on 288 recently isolated bacteria. The activity of cefotetan was generally higher than the 2.generation cephalosporin cefuroxime and lower than the 3.generation cephalosporins tested. In addition, cefotetan was shown to have some antibacterial activity against anaerobic bacteria. Cefotetan is a cephamycin and was found resistant to all 14 plasmid‐mediated and 2 chromosomally‐mediated beta‐lactamases. With its beta‐lactamase resistence and antibacterial activity, cefotetan seems to be a “second‐generation‐like” cephalosporin, almost with 3.generation cephalosporin antibacterial activity against Enterobacteriaceae.
The antibacterial activity of aztreonam, 9 other β-lactam antibiotics and gentamicin was tested in vitro on 383 recently isolated bacteria. The activity of aztreonam against the gram-negative bacteria is similar to the activity of the 3rd generation cephalosporins and gentamicin. With regard to β-lactamase stability only PSE-2 out of 14 plasmid mediated β-lactamases and K-1 out of 2 chromosomally mediated β-lactamases could hydrolyze aztreonam. With its β-lactamase stability, high antibacterial activity and narrow-spectrum aztreonam seems to be a valuable addition to the antibiotic arsenal.
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