A study of the relationships between the sensitivities of Neisseria gonorrhoeae to sodium penicillin G, four semi-synthetic penicillins, spiramycin, and fusidic acid.

Reyn, Alice; Benzon, M.W.

doi:10.1136/sti.44.2.140

Cited by 16 publications

(11 citation statements)

References 28 publications

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“…These findings lend support to the second hypothesis, and are in general agreement with those of Reyn and Bentzon (9,10) and the recent report of Maness and Sparling (6).…”

Section: Resultssupporting

confidence: 82%

Multiple Antibiotic Resistance in Neisseria gonorrhoeae

Maier

Beilstein

Zubrzycki

1974

Antimicrob Agents Chemother

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The sensitivities of gonococcal isolates to six antibiotics were determined for gonococci isolated in Philadelphia in 1972. The degree of association between susceptibilities to any two antibiotics was determined (coefficient of correlation). The correlation between penicillin and tetracycline (r = 0.75) was almost as good as that between two penicillins, penicillin G and ampicillin (r = 0.85), but the difference was statistically significant. The lowest correlation found was between erythromycin and chloramphenicol (r = 0.62), two antibiotics seldom used in gonorrhea therapy. In addition, gonococci most resistant to one antibiotic were the most likely to be multiply resistant. This was found with respect to penicillin, tetracycline, erythromycin, and chloramphenicol. Approximately 40% of gonococci classified as "most resistant" (exceeding the resistance of 75% of all isolates) to one antibiotic were also "most resistant" to three others. Finally, multiply resistant mutants were isolated by selection for resistance to either penicillin or tetracycline. These results provide evidence for the existence of a common mechanism for multiple antibiotic resistance in the gonococcus.

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“…These findings lend support to the second hypothesis, and are in general agreement with those of Reyn and Bentzon (9,10) and the recent report of Maness and Sparling (6).…”

Section: Resultssupporting

confidence: 82%

Multiple Antibiotic Resistance in Neisseria gonorrhoeae

Maier

Beilstein

Zubrzycki

1974

Antimicrob Agents Chemother

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“…The mechanism of penicillin resis tance seemed not to be penicillin /5-lactamase production, since methicil lin is resistant to penicillinase. Penicillin G was more effective against the sensitive strains than ampicillin, but the resistant strains were more sensi tive to ampicillin than to penicillin G, which agrees with earlier studies [6,7]. We also found simultaneous resistance to penicillin and doxycycline (table II), but it was not possible to decide, whether this was due to a common resistance mechanism or to two independent mechanisms pres ent in each strain.…”

Section: Resultssupporting

confidence: 80%

The Disc and Plate Dilution Methods in Determination of the Sensitivity of Neisseria Gonorrhoeae to Penicillin G, Ampicillin and Doxycycline

Jokipii¹,

Renkonen²

1970

Chemotherapy

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We studied the interpretation of the disc method in the determination of the sensitivity of Neisseria gonorrhoeae to penicillin G, ampicillin and doxycycline. The disc sensitivities corresponding to each minimal inhibitory concentration overlapped to the extent that they could not be used to predict MIC. Cross-resistance was found between penicillin G, ampicillin and methicillin. We frequently observed simultaneous resistance to penicillinand doxycycline.

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“…Ampicil lin also seems to be more active than penicillin G against gonococcal strains with a decreased benzyl penicillin sensitivity [18].…”

mentioning

confidence: 99%

A Comparison between Pivampicillin, Ampicillin and Penicillin G in the Treatment of Acute Uncomplicated Gonorrhoea

Malmborg¹,

Molin²,

Nyström³

1973

Chemotherapy

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In the treatment of uncomplicated gonorrhoea pivampicillin, a recently introduced ampicillin derivative with improved oral absorption, has been compared with oral ampicillin and parenteral penicillin G. Pivampicillin was used as a one-day dose of 1.4 g (equimolar to 1 g of anhydrous ampicillin) given in two doses with 5 h interval. Ampicillin was used in a one-day dose of 2 g given in two doses with 5 h interval. Penicillin G was given in a single intramuscular injection of 1.0 MU of benzyl penicillin plus 1.5 MU of procaine penicillin. Each treatment group included 200 patients, 100 of each sex. The rate of probable true recurrence after treatment was similar in the three treatment groups, 4% with pivampicillin, 3% with ampicillin and 3.5% with penicillin G treatment. All drugs were highly effective also in females with gonococci in their rectal specimens.

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A study of the relationships between the sensitivities of Neisseria gonorrhoeae to sodium penicillin G, four semi-synthetic penicillins, spiramycin, and fusidic acid.

Cited by 16 publications

References 28 publications

Multiple Antibiotic Resistance in Neisseria gonorrhoeae

Multiple Antibiotic Resistance in Neisseria gonorrhoeae

The Disc and Plate Dilution Methods in Determination of the Sensitivity of Neisseria Gonorrhoeae to Penicillin G, Ampicillin and Doxycycline

A Comparison between Pivampicillin, Ampicillin and Penicillin G in the Treatment of Acute Uncomplicated Gonorrhoea

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