Since the natural history of untreated Hodgkin's disease cannot be determined by the few case reports in the literature, a study has been made based on the wider experience recorded in the case histories of the patients registered in a large radiotherapy center. An analysis of 323 successive patients treated at the Ontario Cancer Institute, Toronto, who have been followed more than 10 years has revealed at least 2 different patterns in the course of Hodgkin's disease—one potentially curable, the other not yet fully understood. These 2 forms usually can be identified at the time of diagnosis. When this is possible more adequate radiotherapy can be prescribed. The finding of 2 separate clinical courses fits in with the epidemiological concept of 2 different populations in Hodgkin's disease which have been identified by studies in age incidence.
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