SummaryThe development of a labeling method for secondary amines with [2-11 C]acetone is described since the R 2 N-isopropyl moiety is present in many biologically active compounds. The influence of a variety of parameters (e.g. reagents, solvents, temperature, and time) on the reaction outcome is discussed. Under the optimal reaction conditions, [ 11 C]1-isopropyl-4-phenylpiperazine ([ 11 C]iPPP) was synthesized from [2-11 C]acetone and 1-phenylpiperazine in a decay-corrected radiochemical yield of 72%.
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