Improved and semi-automated GMP-compliant radiosynthesis of [11C]docetaxel

Tilburg, Erica W. van; Mooijer, Martinus; Brinkhorst, Johan; Meij, M. van der; Windhorst, Albert D.

doi:10.1016/j.apradiso.2008.02.076

Cited by 9 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To this end, docetaxel was labeled with the short-lived positron emitting radionuclide carbon-11, resulting in [ 11 C]docetaxel with an identical molecular structure as the drug docetaxel itself (3,4). Using [ 11 C]docetaxel and positron emission tomography (PET), microdosing studies can be carried out to monitor pharmacokinetics and pharmacodynamics of docetaxel noninvasively in patients.…”

Section: Introductionmentioning

confidence: 99%

Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography

Veldt

Lubberink

Greuter

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography

Veldt

Lubberink

Greuter

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

“…The chemical formula of paclitaxel is C47H51O14 and its molecular weight is 853.9 gÁmol/L, whereas the chemical formula of docetaxel is C43H53NO14 with a molecular weight of 807. (16,17) are identical to those of the parent drugs, as a stable carbon atom is replaced by carbon-11 ( Fig. 1D and E).…”

Section: Radiolabeling Of Taxanesmentioning

confidence: 91%

“…Nevertheless, treatment failure of taxanes occurs and patients are often subjected to numerous hematologic and nonhematologic toxicities without gaining benefit. At present, two radiolabeled taxanes, paclitaxel and docetaxel, are available as PET tracers (13)(14)(15)(16)(17).…”

Section: Taxanesmentioning

confidence: 99%

“…Anatomical localization of tracer uptake is provided by low-dose computed tomography (CT), which is integrated in state-of-the-art PET-CT scanners (20). As mentioned above, both paclitaxel and docetaxel have been labeled with positron emitters (13)(14)(15)(16)(17), thereby enabling PET studies to monitor pharmacokinetics and pharmacodynamics of these taxanes noninvasively (21).…”

Section: Positron Emission Tomographymentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Imaging as a Pharmacodynamic Marker

Veldt

Lammertsma

2014

Clinical Cancer Research

View full text Add to dashboard Cite

Although numerous anticancer drugs are widely used in the clinic, many questions remain about pharmacokinetics, biodistribution, toxicities, and efficacy. Positron emission tomography (PET) using radiolabeled drugs is a promising method to further understand the clinical behavior of anticancer agents. In addition, it may contribute to better guided treatment planning in individual patients with cancer. Among the available anticancer drugs, considerable experience has been gained with radiolabeling taxanes. At present, two radiolabeled taxanes, paclitaxel and docetaxel, are available as PET tracers.

show abstract

“…Previously, docetaxel has been labeled with the positron-emitting radionuclide carbon-11 (8,9), and it has been shown that a dynamic PET scan, following a tracer dose of radiolabeled docetaxel ([ 11 C]docetaxel), provides a quantitative measurement of [ 11 C]docetaxel kinetics in patients with lung cancer (10). In the latter study, tumor kinetics of [ 11 C]docetaxel were found to be highly variable.…”

Section: Introductionmentioning

confidence: 99%