The thyroid gland, a highly vascular endocrine gland, is composed of two lateral lobes connected by a narrow median isthmus thus giving an 'H' shaped appearance to the gland. A wide range of morphological variations and developmental anomalies of the thyroid gland have been reported in the literature. In our study, on the morphometric features of the thyroid gland it was found that, 6 out of 41 thyroid glands that were dissected, showed an absence of the isthmus. The respective lateral lobes were positioned independently on either side of the trachea. The incidence of agenesis of isthmus, along with the developmental and clinical significance are discussed herein under.
Introduction: The knowledge of renal vascular anatomy and its variations are very much essential in case of renal transplantation, renal surgeries, uroradiology, gonadal color doppler imaging, in surgeries of aneurysm of abdominal aorta, in gonadal surgeries.
To the Editor, Anatomical Sciences Education: We read the recent Anatomical Sciences Education articles by Harmon et al. (2021) and Attardi et al. (2022) with great interest. These studies rendered a clear picture of the paradigm shifts in anatomy teaching before and during the Covid-19 pandemic. The authors found that there was a significant decrease in face-to-face interactions and cadaver-based instructions because compulsory lockdowns have necessitated virtual classes to maintain student safety
With the flourishing of innovation in drug discovery into a new era of personalized therapy, the use of monoclonal antibodies (mAbs) in the treatment of various ailments lies at the forefront. Major improvements in genetic sequencing and biomedical techniques as well as research into mAbs emphasize on determining new targets for advanced therapy while maximizing efficacy for clinical application. However, a balance has to be achieved concerning developing a target with low toxicity combined with high specificity and versatility, to allow a specific antibody to facilitate several biotic effects, ranging from neutralization of virus mechanisms to modulation of immune response and maintaining low global economic cost. Presently, there are approximately 30 mAbs' permitted for therapeutic use with many more being tested in clinical trials. Nevertheless, the heavy cost of mAbs' production, stowage and management as well as the subsequent hindrances to their development are outweighed by mAbs' clinical advantages. Compared to conventional drugs, since mAbs use as pharmacologic iotas have specific physical features and modes of action, they should be considered as a discrete therapeutic category. In this review, the history of mAb generation and the innovative technological applications of mAbs that has advanced in clinical practices is reviewed.
The respiratory diaphragm is a barrier between the thoracic and abdominal cavities. It is a chief skeletal muscle of respiration that plays a critical role in the process of inspiration. The defective diaphragm may be clinically present with or without obvious symptoms. Depending on the severity of its defects, it can lead to mild to severe fatal consequences. Protrusion of abdominal contents into the thoracic cavity through the weakened or defective part of the diaphragm is known as a diaphragmatic hernia. Such herniations will exist either in the form of congenital birth defects or acquired defects in the diaphragm. An acquired hernia may be due to spontaneous or iatrogenic causative factors. Congenital Diaphragmatic Hernia (CDH) can occur due to the disruption of various cellular mechanisms involved in organogenesis during the gestation period. Such herniations may exist with or without content protrusions into the cavity of the thorax, later referred to as Eventration of the Diaphragm (ED). In the Department of Anatomy at JSS Medical College, Mysuru, Karnataka, India, a rare case of diaphragmatic eventration was noticed in a male cadaver aged about 70 years, during the routine dissection class of preclinical medical students. In this rare case report, diaphragmatic eventration along with various factors involved in its presentation would be considered holistically
Hyperostosis is a slow-growing benign bone tumour often seen in the bones of the cranial vault, more commonly found in elderly females. It is an incidental finding noted during radiological examination. The clinical manifestation of such tumour depends on its location inside the cranial cavity: the proximity to the paranasal sinuses, brain tissue, nerves, or blood vessels, etc. Its clinical findings may range from mild obstruction of the paranasal sinuses or blood vessels to severe compression of the surrounding cranial nerves. Here a rare case of hyperostosis of the frontal and temporal bones found during a routine cadaveric dissection in the Department of Anatomy is presented. Causes of the formation of such unusually enlarged bone masses inside the cranial cavity and their clinical presentation are discussed.
Most of the soft tissue calcified mass formations are sporadic incidences that occur in an idiopathic form. Ectopic calcification changes were seen in various soft tissues beyond the skeleton. They are often asymptomatic masses located in the superficial or deeper aspect of the body, but may not be related to the bone directly. Increased levels of serum calcium, phosphate, or Vitamin D hypervitaminosis may be associated with the calcification process, causing mass accretion in the tissues like bones of limbs, and cranium, or showing some dental abnormalities. During the routine dissection of the hamstring compartment of the left lower limb in a male cadaver aged around 70 years in the Department of Anatomy, we noticed nodular fragments and lengthy slender pieces, which were hard in consistency and bony in its appearance found within the semimembranosus muscle. The histopathology of these masses was revealed as “Dystrophic Calcified Masses”. A holistic description of calcification changes in the soft tissues will be considered in the article. Keywords: calcification, dystrophy, hypervitaminosis
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.