Стоматология 2, 2015Стоматология детСкого возраСта Буллезный эпидермолиз (БЭ) представляет собой группу редких наследственных заболеваний, характери-зующихся нарушением межклеточных контактов в эпи-дермисе или дерме, что при малейшей травме приводит к образованию пузырей на коже и слизистой. В зависи-мости от вида молекулярных нарушений и уровня рассло-ения кожи выделяют 3 основных типа БЭ: простой (воз-никает вследствие нарушения выработки кератина-14, расслоение на уровне эпидермиса); пограничный (де-фект ламинина-5, пузыри возникают на границе эпи- Ключевые слова: буллезный эпидермолиз, лечение зубов.
The article presents classification of the thermosetting materials for bone augmentation. The physical, mechanical, biological, and clinical properties of such materials are reviewed. There are two main types of curable osteoplastic materials: bone cements and hydrogels. Compared to hydrogels, bone cements have high strength features, but their biological properties are not ideal and must be improved. Hydrogels are biocompatible and closely mimic the extracellular matrix. They can be used as cytocompatible scaffolds for tissue engineering, as can protein- and nucleic acid–activated structures. Hydrogels may be impregnated with osteoinductors such as proteins and genetic vectors without conformational changes. However, the mechanical properties of hydrogels limit their use for load-bearing bone defects. Thus, improving the strength properties of hydrogels is one of the possible strategies to achieve the basis for an ideal osteoplastic material.
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