Development prospects of curable osteoplastic materials in dentistry and maxillofacial surgery

Vasilyev, A. V.; Кузнецова, В. С.; Бухарова, Т. Б.; Grigoriev, T. E.; Zagoskin, Yu. D.; Korolenkova, M V; Зорина, О А; Чвалун, С. Н.; Goldshtein, D. V.; Aa, Kulakov

doi:10.1016/j.heliyon.2020.e04686

Cited by 12 publications

(9 citation statements)

References 189 publications

(171 reference statements)

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“…Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers [ 37 , 38 , 39 ], and many biomedical applications of alginates are in the form of hydrogels, including wound healing, drug delivery and tissue engineering [ 5 , 14 , 40 , 41 ]. Since the first report of its utility in insulin microencapsulation in 1980, alginate hydrogel has become the most widely used functional material for cell encapsulation and drug carrier [ 42 ].…”

Section: Preparation and Processing Technology Of Alginatesmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field. The present review provides an overview of the properties and processing methods of alginates, as well as their applications in wound healing, tissue repair and drug delivery in recent years.

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Section: Preparation and Processing Technology Of Alginatesmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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“…The intended use of HA in dentistry is mainly the regeneration of soft tissues, but also wound healing and regeneration of hard tissues. HA may be used as a co-material (together with other biopolymers) in several procedures related to dentistry: papilla reconstruction, osseointegration of implants, sinus lifting, periodontitis, and stomatitis therapy [ 46 , 47 , 48 , 49 ].…”

Section: Applications Of Hyaluronic Acidmentioning

confidence: 99%

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

et al. 2021

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This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.

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“…Подібні втручання поширені в хірургії, травматології, онкології і зокрема в стоматології. Проблема регенерації кісткової тканини є однією з найактуальніших у сучасній хірургічній стоматології і щелепно-лицевій хірургії [2]. Зубоальвеолярні дефекти щелепних кісток дуже поширені і є серйозною проблемою в стоматологічному лікуванні та реабілітації [3].…”

Section: вступunclassified

Assessment of the Intensity of Pain Syndrome and Collateral Swelling During the Socket Augmentation After Tooth Extraxtion With Different Osteoplastic Materials

Бамбуляк

Kuzniak

Dmytrenko

et al. 2021

Act. Probl. of the Modern Med.

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The article presents a comparative analysis of the clinical effectiveness of osteoplastic materials, in particular a preparation based on multipotent mesenchymal stromal cells of adipose tissue and platelet-enriched plasma used to fill bone defects during the socket augmentation after the tooth extraction. The criteria to assess the therapy effectiveness at the stage of the early postoperative period included the intensity of pain and the amount of collateral oedema after surgery. The aim of this study is to evaluate the clinical effectiveness of osteoplastic materials to augment the volume of the alveolar bone during the operation of socket augmentation after the tooth extraction. Setting of this study: Bukovynian State Medical University, Chernivtsi, Ukraine. The study included 85 patients. The procedure of socket augmentation was performed by using "Kolapan - L" (28.57% of individuals, subgroup A), by combinations of MMSK AT + "Kolapan - L" + PRP (46.43% of individuals, subgroup B); the subgroup C included individuals (25.0%) whose wounds after tooth extraction healed by the formation a blood clot. The assessment of postoperative pain was performed by applying the digital rating scale (Numerical Rating Scale, NRS), taking into account the subjective pain in the patients. The subjects underwent visual assessment of the severity of collateral oedema after the tooth extraction surgery. To determine the dynamics of the severity of oedema we used a scoring system. The study demonstrated the patients of the subgroup B, who received the socket augmentation with "Kolapan - L" + MMSC-AT + PRP, experienced no pain at the final stage of postoperative observation (89.31% of cases) that was 1.2 times higher (p1 <0.05) than in the patients of subgroup A (p> 0, 05). At the final postoperative stages, no collateral oedema was seen in 98.47% of the participants of the subgroups B that exceed the number of cases in the subgroup A where the bone defect was augmented by "Kolapan - L", in 1.2 times (p1 <0.05). A comparative analysis of the clinical effectiveness of osteoplastic materials to increase the volume of the alveolar bone in the jaws during the socket augmentation after the extracted tooth convincingly proved the advantage of using the combination of "Kolapan - L" + MMSС - AT + PRP that was also confirmed by signs and symptoms in the postoperative period.

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Development prospects of curable osteoplastic materials in dentistry and maxillofacial surgery

Cited by 12 publications

References 189 publications

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Assessment of the Intensity of Pain Syndrome and Collateral Swelling During the Socket Augmentation After Tooth Extraxtion With Different Osteoplastic Materials

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