Myelopeptide-2 (MP-2; Leu-Val-Val-Tyr-Pro-Trp), originally isolated from the supernatant of porcine bone marrow cell culture, is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from HL-60 leukemia cells or measles virus. This effect is based on the ability of MP-2 to recover the reduced interleukin (IL)-2 synthesis and IL-2 receptor (IL-2R) expression in human T lymphocytes treated with these harmful agents. The involvement of other cytokines in MP-2 restoration of the reduced IL-2 synthesis in T lymphocytes is experimentally studied. It is shown that T helper (TH) 1 and TH2 cytokines are acting in close interaction, the character of which depends on the immune status of the T-lymphocyte donors. The data obtained allow one to suggest that the MP-2 involvement in regulatory processes is directed to the maintenance of immune homeostasis. This peptide is perspective to be applied in antitumor and antivirus therapy.
Myelopeptide-5 (MP-5; synthetic analog of endogenous low-molecular-weight peptide Val-Val-Tyr-Pro-Asp) neutralized the immunosuppressive effects of antiviral vaccines (influenza, measles, and measles/parotitis) and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4(+) lymphocyte (its target cell) was studied using [(3)H]MP-5 (dissociation constant 2.03 x 10(-7) M).
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