2 Белорусский государственный медицинский университет, Минск, Республика Беларусь 3 Минский городской клинический онкологический диспансер, Минск, Республика Беларусь МИКРООКРУЖЕНИЕ ОПУХОЛЕВЫХ КЛЕТОК ПРИ АДЕНОКАРЦИНОМАХ ТОЛСТОЙ КИШКИ Аннотация. В работе применен электронно-микроскопический метод для анализа клеток стромального компонента рака толстой кишки. В ходе исследования обнаружены клетки гематогенного и мезенхимального происхождения с измененными ультраструктурами. Ключевые слова: колоректальный рак, стромальное микроокружение, ультраструктурное исследование Для цитирования: Микроокружение опухолевых клеток при аденокарциномах толстой кишки / М. А. Деревянко [и др.] // Вес. Нац. aкад. навук Беларусі. Сер. мед. навук.Abstract. An electron microscopic method for analyzing the cells of the stromal component of colon cancer has been applied. During the study, cells of hematogenous and mesenchymal origin with altered ultrastructures were found.Keywords: colorectal cancer, stromal microenvironment For citation: Derevyanko M. A., Rjabceva S. N., Fridman M. V., Derevyanko I. A., Zalutskii I. V. Microenvironment of tumor cells in colon adenocarcinomas. Vestsi Natsyyanal'nai akademii navuk Belarusi. Seriya meditsinskikh navuk =
| №1 (191) | Январь 2019 | НАУКА И ИННОВАЦИИ ht t p:// innos fe ra . by НАУЧНЫЕ ПУБЛИКАЦИИ Summary. The article presents the results of an immunohistochemical study of the expression of the markers matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinases-1 in patients with colon adenocarcinoma. The structural components in which expression of MMP-9 is possible are revealed: tumor cells, large epithelioid-like cells, inflammatory cells, fibroblasts. The findings suggest that the protease and its tissue inhibitor are unevenly distributed between tumor and stromal colon cancer cells.There is an increase in the frequency of a positive reaction in the epithelial cells of the tumor in a state of epithelial-mesenchymal transition in patients with metastases. Keywords: colon cancer, matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinases-1, stromal microenvironment.
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