Summary. Serotonin stimulated insulin release, independently of glucose, from rabbit pancreatic tissue in vitro. A concentration of 100 ~g/ml gave a maximal insulin release. Higher concentrations delayed insulin release. --The simultaneous incubation with serotonin and glucose led to a slight decrease in insulin release. This decrease in insulin release rose with increasing serotonin coneentrations. --The insulin production induced by serotonin stinmlation (100 ~g/ml) was quantitatively equivalent to the maximal amount of insulin released by 2 mg glucose per ml, and by 1 mg of tolbutamide per ml. --The significance of these findings with regard to the difference in the results obtained with the oral as compared with the intravenous glucose tolerance test, and with respect to the pathogenesis of both the dumping and the carcinoid syndromes were discussed.
In mammals calcitonin is secreted by the C-cells of the thyroid and stimulated by hypercalcemia (Co Cameron Chene Davidson and Henze, 1962; Kumar, Foster and McIntyre, 1963; Care, 1965 • In birds and other species calcitonin is produced by the ultimobranchial organ (~, 1967). ~tried to study calcitonin secretion by the perfused ultimobranchial gland of the hen.
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