The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones

Goberna, R.; Fußgänger, R.; Raptis, Sotirios A.; Telib, M; Pfeiffer, E. F.

doi:10.1007/bf00443883

Cited by 21 publications

(6 citation statements)

References 10 publications

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“…These findings strongly support the results of the present in vivo study. Goberna et al (1971) found a normal insulin release and a normal glucose tolerance in the fasted, anaesthetized rat 3 4 weeks after duct-ligation. They also noted an absent insulin response to a secretin load in duct-ligated animals.…”

Section: Discussionmentioning

confidence: 78%

Influence of pancreatic duct ligation on endocrine and exocrine rat pancreas

Isaksson

Ihse

Lundquist

1983

Acta Physiologica Scandinavica

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A parallel investigation into endocrine and exocrine pancreatic function, after duct-ligation in the rat, was performed to study the effect of reduced intestinal trypsin levels on insulin secretion and glucose tolerance. Animals with only a slight exocrine insufficiency displayed a normal insulin secretion and a normal glucose tolerance 4 weeks after operation. At 4-5 month s these animals showed a slight increase in glucose-induced insulin release when compared with control rats. However, animals operated on with a more complete ligation of the pancreatic ducts, who showed a marked exocrine insufficiency accompanied by decreased levels of intestinal trypsin, displayed a markedly increased insulin secretory response to intravenous glucose and an increased glucose tolerance. The results lend further support to our previous suggestion that, in the rat, the levels of intestinal trypsin may influence insulin secretory processes via complex feed-back mechanisms which may involve cholecystokinin and/or other intestinal hormones.

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Section: Discussionmentioning

confidence: 78%

Influence of pancreatic duct ligation on endocrine and exocrine rat pancreas

Isaksson

Ihse

Lundquist

1983

Acta Physiologica Scandinavica

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“…From their studies these authors postulate competition of MH with glucose for the same membrane carrier causing glucose depletion within the cello This point of action is supported by data of Kanazawa, Orci and Lambert (1971). The presence of glucose probably is not essential for the stimulatory effect of PZ, as demonstrated by Goberna et al (1971) and Hinz et al (1971). These authors demonstrate, however, the markedly enhancing stimulatory effect of glucose even in substimulatory concentrations.…”

Section: Discussionmentioning

confidence: 83%

Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Pancreozymin in Rabbits

Lucke¹,

Höffken²,

Hj³

et al. 1974

Horm Metab Res

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“…In rats, alteration in glucose metabolism, as indicated by normal fasting glucose levels [6], as well as normal kinetics of glucose and ll~I during an i.v. GTT [7], could not be observed within the first weeks following the surgery procedure. 5--8 months after duct ligation the blood glucose rose above normM [6].…”

Section: Discussionmentioning

confidence: 85%

“…Furthermore, dogs developed an abnormal i.v. GTT, but rabbits and rats [7] did not. Little is known about the response of duct ligated animals to an intragastric glucose load.…”

Section: Discussionmentioning

confidence: 89%

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Glucose tolerance and insulin secretion in rabbits and dogs after ligation of the pancreatic ducts

Heptner¹,

Neubauer²,

Schleyerbach³

1974

Diabetologia

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The present studies on duct ligated dogs and rabbits are an attempt to demonstrate functional alterations in glucose metabolism: 1. In rabbits the insulin reserve in the pancreatic gland was reduced to about one fifth of its normal value. 2. In dogs, as well as in rabbits, the values of fasting blood glucose remained norreal for a period of 12 months following the operation. In rabbits the intragastric, but in dogs both the intragastric and the intravenous glucose tolerance were impaired. 3.In duct ligated dogs, the increase in serum IRI was diminished after intragastric and i.v. glucose load, as well as after injection of glucagon. Attempts are being made to adapt the model for special studies concerning the early state of diabetes.

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The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones

Cited by 21 publications

References 10 publications

Influence of pancreatic duct ligation on endocrine and exocrine rat pancreas

Influence of pancreatic duct ligation on endocrine and exocrine rat pancreas

Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Pancreozymin in Rabbits

Glucose tolerance and insulin secretion in rabbits and dogs after ligation of the pancreatic ducts

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