MicroRNAs (miRs) are small non-pro tein-en cod ing RNAs of 20-30 nu cleo tides long. In eukaryotic cells miRs play the role of bioregulators of gene ex pres sion through the mech a nisms of trans la tion re pression/mod u la tion. Here we both fa mil iar ize the read ers with miRs biogenesis, func tion ing mech a nisms, and strat egy of their dis cov ery and pres ent the list of bi o log i cal pro cesses, reg u lated by miRs. We also list the pub li ca tions, ded i cated to miRs role in hu man pa thol o gies (carcinogenesis in par tic u lar) and their ap pli cation for mark ing, pre ven tion, di ag nos tics, and ther apy of can cer.
Выяснено строение 76 триптических пептидов каталазы P. vitale. 63 пептида содержат неперекрывающиеся аминокислотные последовательности, включающие 584 остатка аминокис лот. Это составляет 83 % длины полипептидной цепи, установленной с помощью рентгеноструктурного анализа [Ї].
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