Harrison et al. [22] studied the metabolism of meropenem and *Corresponding author: Sreedhar NY, Electroanalytical Lab, Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India, Tel: +91-9440087124; E-mail: sreedharny.chem@gmail.com
AbstractThe theme of this study was the preparation, characterization, and application of a polyaniline (PAN) and graphene composite modified glassy carbon electrode (PAN/Gr/GCE) for the voltammetric determination of doripenem (DPM) and meropenem metabolites (MPM) in human urine and serum samples. The morphological study of the PAN/ Gr/GCE composite was examined by scanning electron microscopy (SEM) and cyclic voltammetry (CV). The electrochemical behaviour of DPM and MPM at the PAN/Gr/GCE were investigated using cyclic voltammetry in Ag/ AgCl/KCl supporting electrolyte at pH 2.0-10.0 in phosphate buffer solution. The linear dependence of current versus concentration was reached in a wide concentration range from 2.5×10 -7 M to 3.5×10 -4 M using cyclic voltammetry and differential pulse voltammetric methods. In acidic media a non-reversible diffusion controlled reduction involving two protons and two electrons occurs at carbon and nitrogen double bond (C=N) in the metabolites. The best electroanalytical performances of this composite electrode were achieved with the detection limits 3.6×10 -9 M and 1.75×10 -9 M for DPM and MPM respectively. The simplicity of preparation, high sensitivity and stability of this composite electrode should open novel avenues and applications for fabricating robust sensors for detection of DPM and MPM in human urine and serum samples.
The electrochemical behavior of vinclozolin [3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3 oxazolidine-2,4-dion] in dimethylsulfoxide was performed by cyclic voltammetry (CV) and linear sweep voltammetry (LSV). The main decomposition pathway included in the cleavage of chlorine atoms at platinum electrode. The general reduction mechanism of this compound has been suggested based on the results obtained. The peak potential and peak current were found to be depending on pH of the buffer solution. The measuring system response was linear over the vinclozolin concentration range from 1.0×10-3 to 5.0×10-7 mol L-1 and the detection limit (LOD) achieved was 1.1×10-8 mol L-1 (2.5 µg L-1) at pH 4.0. Vinclozolin was determined in spiked serum sample.
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