Graphene and Polyaniline Composite Modified Glassy Carbon Electrode for Electrochemical Determination of Doripenem and Meropenem Metabolites

Sivaprasad, M.

doi:10.4172/2155-9872.1000192

Cited by 15 publications

(10 citation statements)

References 23 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, selectivity is a critical pharmacodynamic parameter to be addressed for effective therapeutic monitoring. The selectivity of the molecularly imprinted sensors is chiefly governed by the imprinting reactions [ 39 ]. In this regard, the selectivity of the prepared MIP sensors was tested with drugs that have a similar structure to that of the target drug ( Table 1 ), along with the test on untreated CP electrodes.…”

Section: Resultsmentioning

confidence: 99%

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Aaryashree

Takeda

Kanai

et al. 2020

Sensors

View full text Add to dashboard Cite

An inexpensive disposable electrochemical drug sensor for the detection of drugs (vancomycin, meropenem, theophylline, and phenobarbital) is described. Molecularly imprinted polymer (MIP) templated with the target drugs was immobilized on the surface of graphite particles using a simple radical polymerization method and packed into the working electrode of a three-electrode ceramic-based chip sensor. Differential pulse voltammetry (DPV) was used to determine the relationship between the response current and the concentration of the targeted drug while using one sensor chip for one single operation. The time required for each DPV measurement was less than 2 min. Concentrations corresponding to the therapeutic range of these drugs in plasma were taken into account while performing DPV. In all the cases, the single-used MIP sensor showed higher sensitivity and linearity than non-imprinted polymer. The selectivity test in drugs with a structure similar to that of the target drugs was performed, and it was found that MIP-based sensors were more selective than the untreated ones. Additionally, the test in whole blood showed that the presence of interfering species had an insignificant effect on the diagnostic responses of the sensor. These results demonstrate that the disposable MIP-sensor is promising for quick and straightforward therapeutic drug monitoring to prevent the toxic side effects and the insufficient therapeutic effect due to the overdose and underdose, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Aaryashree

Takeda

Kanai

et al. 2020

Sensors

View full text Add to dashboard Cite

show abstract

“…Electrochemical determination of meropenem with doripenem by modified electrode is available in literature 24 . To date no electrochemical method is available in literature for determination of meropenem in human plasma by square wave stripping mode.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Studies of Meropenem at Glassy Carbon Electrode and its Direct Determination in Human Plasma by Square Wave Anodic Adsorptive Stripping Voltammetry

2016

Chem Sci Trans

View full text Add to dashboard Cite

Abstract:In present study a sensitive and fast square wave anodic adsorptive stripping voltammetric method was developed for the trace analysis of antibacterial drug meropenem in human plasma at glassy carbon electrode. The oxidation of meropenem gave a well-defined peak in Britton Robinson buffer at glassy carbon electrode. The process was diffusion controlled. A linear response was obtained between 1.0x10 -7 to 4.0x10 -5 M in aqueous media. The recovery studies were also achieved to check sensitivity and accuracy of the method. The proposed method was applied for the determination of meropenem in body fluids without any time-consuming extraction, separation, adsorption steps. The value of limit of detection (LOD) for human urine and human serum samples was found to be 2.27x10 -6 M and 1.67x10 -6 M respectively.

show abstract

“…Excellent green chemical analysis of our proposed method; accompanied with higher sensitivity is achieved if compared to other methods upon classical electrodes [17][18][19] and toxic polyaniline/graphene modified electrode 20 applications. Polyaniline is investigated as an environmentally toxic and teratogenic material.…”

Section: Application On Commercial Vials and Standard Additionmentioning

confidence: 99%

Green Insight of High Performance UTGE Operation in Nano-Sensitive Electro-Analysis of Meropenem by Adsorptive Stripping Voltammetry

Fayed

Youssif

Hendawy

et al. 2018

J. Electrochem. Soc.

View full text Add to dashboard Cite

The present study concerns with investigation of the electrochemical activity of meropenem (MP) at ultra-trace graphite electrode (UTGE). The electrochemical measurements were performed in various buffer solutions in pH range (2.0-8.0). One irreversible anodic peak was observed in acidic medium. The effects of pH and scan rate on the peak current and potential were studied. The adsorption-controlled nature of MP peak was demonstrated. Therefore, it is directed to develop adsorptive stripping square wave voltammetric technique (AdS-SWV) for quantitative determination of MP in drug substance, pharmaceutical vials and in presence of interference substances. Under optimum experimental conditions, a linear dependence relationship was obtained over MP concentration range of 500.0-15000.0 nM. The limits of detection (LOD) and quantification (LOQ) were 160.0 and 470.0 nM respectively. Chemical safety is assessed at different aspects. Qualitative and quantitative metrics reveal excellent eco-friendly voltammetric method. In spite of high budget of UTGE; multiple merits of nano-sensitivity, selectivity, greenness evidence and high efficiency encourage wide application of our developed method in QC using UTGE in comparison to other chemically-modified electrodes.

show abstract

Graphene and Polyaniline Composite Modified Glassy Carbon Electrode for Electrochemical Determination of Doripenem and Meropenem Metabolites

Cited by 15 publications

References 23 publications

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Electrochemical Studies of Meropenem at Glassy Carbon Electrode and its Direct Determination in Human Plasma by Square Wave Anodic Adsorptive Stripping Voltammetry

Green Insight of High Performance UTGE Operation in Nano-Sensitive Electro-Analysis of Meropenem by Adsorptive Stripping Voltammetry

Contact Info

Product

Resources

About