The etiology of uveitis and its associated systemic findings may vary depending on the geographic distribution of patients and local factors. These results represent those of patients with uveitis referred to hospitals in central Anatolia.

We report two cases of decompression retinopathy. Predisposing risk factors and possible mechanisms are discussed. Case reportsCase 1

These results could be helpful in the diagnosis and follow-up of obese children.

Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of topical Coenzyme Q10 + Vitamin E (CoQ + Vit.E) molecules on retinal ganglion cells. Methods: Mechanic optic nerve injury model was created in the right eyes of rats (n = 12). Rats were divided into two groups: glaucoma model with sham treatment and topical CoQ + Vit.E treatment. Treatment was applied for 4 weeks. Glial fibrillary acidic protein, Brn-3a antibody, and anti-Iba1 were examined by immunohistochemistry. Glial fibrillary acidic protein, Bax, Bcl-xL, and Tfam protein expression were measured by Western blot analysis. Results: The number of Brn-3a-positive retinal ganglion cell was 15.0 ± 1.0 (min: 14, max: 16) in sham treatment group and 22.2 ± 4.8 (min: 18, max: 29) in topical CoQ10 + Vit.E treatment group. The protection of Brn-3a in CoQ10 + Vit.E was statistically significant (p < 0.05). Glial fibrillary acidic protein–positive astroglial counts were recorded as 11.7 ± 2.1 (min: 10, max: 14) in sham treatment and 2.5 ± 1.5 (min: 1, max: 4) in topical CoQ10 + Vit.E treatment group (p < 0.05). Topical CoQ10 + Vit.E treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. CoQ10 + Vit.E treatment prevented apoptotic cell death by increasing Bcl-xL protein expression. Also, CoQ10 + Vit.E preserved Tfam protein expression in the retina. Conclusion: This study has shown that in glaucoma treatment the neuron protecting effect of topical CoQ10 + Vit.E molecules can be valuable.

Phaco-NPDS surgery achieved excellent IOP control, while also providing immediate visual recovery. The success rate was similar to that of the NPDS procedure alone. It is advisable to consider Phaco-NPDS as a primary surgery for patients with coexisting cataract and open angle glaucoma, including PXG.

We aimed to analyze the effects of progressive myelin loss and neurodegeneration seen in patients with multiple sclerosis (MS) on visual tract with electrophysiological and structural tests. Fifty-one patients diagnosed with MS in the Neurology Department were followed up in neuro-ophthalmology outpatient clinic irrespective of their visual symptoms, and were included in our study. The patients were classified as the ones with the history of optic neuritis (group II) and ones without the history (group I) of optic neuritis. The data, including clinical presentation, retinal nerve fiber layer thickness (RNFLT) measurements, pattern visual evoked potential (pVEP) and flash electro retino grams (ERG) test results, were recorded. In our study, comparison of pVEP test latencies of groups I and II with each other, and with those of healthy subjects revealed statistically significant differences (p < 0.05). The analysis of rod functions on ERG did not show any significant changes (p > 0.05). However, both groups showed significantly decreased cone b-wave amplitudes, elongation of latencies, and decreased flicker amplitudes on cone and flicker potentials obtained after light adaptation (p < 0.05). There was significant thinning in RNFLT of the both groups when compared to the normal standards. The difference between two groups was statistically significant (p < 0.05). Axon loss is seen in the optic nerve with subclinical or acute optic neuritis in patients with MS. RNFLT analysis and electrophysiological tests are of great importance in diagnosis of MS, as well as to determine progression and to direct neuroprotective therapy in patients diagnosed with MS. Objective analysis methods gain more importance in the diagnosis and follow-up of MS patients, parallel to technological advancements.

No abstract

Purpose: To compare amblyopic eyes and other eyes of the unilaterally amblyopic patients in the terms of pattern visual evoked potentials (pVEP), pattern electroretinogram (pERG) and flash electroretinogram(fERG) tests. Methods:This study was performed at Ankara Numune Training and Research Hospital between November-2015 and August-2016. Forty-one patients above the age of 15 with anisometropic amblyopia were evaluated for their amblyopic and other eyes. The patients were tested by Metrovision brand monpack model visual electrophysiology device for pVEP, fERG and pERG tests. Mean latance and amplitudes were examined statistically.Results: A statistically significant difference was found in decrease of P100 amplitude (p<0.05) and increase of P100 latency (p<0.01) of amblyopic eyes in all 5 patterns pVEP recorded. In pERG results P50 and N95 wave amplitudes were decreased in amblyopic eyes (p<0.01) but there was no statistical difference in latency period between amblyopic eyes and other eyes (p>0.05). In fERG results, rod response b wave amplitudes was lower and latency was increased in amblyopic eyes (p<0.01). However cone responses were no statistical difference in amblyopic and other eyes (p>0.05). Conclusion:According to our results, amblyopia is not only a cortical pathology. Also cortico-retinal pathologies that can not be detected by routine opthalmologic examination may accompany amblyopia. pERG, fERG and pVEP are objective methods for diagnosis and follow up of amblyopic patients and valuable guides for clinicians.