Electrophysiologic evaluation of amblyopia

Hamurcu, Mualla; Çelik, Ayşenur; Saricaoğlu, M. Sinan; K.Bulut, Ayten

doi:10.15761/ecv.1000112

Cited by 4 publications

(4 citation statements)

References 18 publications

(26 reference statements)

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Section: Discussionsupporting

confidence: 77%

“…10,11 Other authors stated that amblyopic eyes showed a significant delay in P100 latency of PVEP in comparison to the non-amblyopic and control eyes, which may be related to prolonged conduction between the retina and cortex. 12,13 The same was found by Azmy and Zedan (2016) who reported such significant delay in P100 latency of PVEP of amblyopic eyes when compared to non-amblyopic eyes in strabismic amblyopia. 14 In the present study, the amplitude of the P100 response of the PVEP showed no significant difference between Group 2 and Group 3, either in anisometropic (Group 2A) or strabismic types (Group 2B), which was consistent with Azmy and Zedan (2016) 14 and De Mendonça et al ( 2013), 15 who stated that there was no significant difference in the P100 amplitude of the PVEP between both eyes in unilateral strabismus.…”

Section: Discussionsupporting

confidence: 72%

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Assessment of amblyopic children undergoing occlusion therapy by pattern visual evoked potentials and contrast sensitivity tests

Nada

Gohary

Azmy

et al. 2023

European Journal of Ophthalmology

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Background: Amblyopia is a case where one or less commonly, both eyes have impaired visual performance, even with the best optical correction and no visible disease of the visual system. Objectives: To assess contrast sensitivity tests (CST) and pattern visual evoked potentials (PVEP) results in amblyopic children who have already started occlusion therapy for durations ranging from 6 to 12 months. Methods: This cross-sectional study was conducted on 200 eyes of 50 patients with monocular amblyopia and 50 age and sex matched controls. Both patients and controls underwent ophthalmological assessment, PVEP, and CST. Results: There was no statistically significant difference in the results of P100 latencies of qualitative PVEP in amblyopic eyes compared to non-amblyopic eyes and control eyes, while the qualitative CST showed a highly statistically significant difference, being affected in 98% of amblyopic eyes compared to unaffected eyes (4%) and control eyes (4%). The maximum contrast level and minimal contrast level of quantitative CST were significantly lower in amblyopic eyes compared to non-amblyopic and control eyes. The cutoff value of maximal contrast level at mean frequencies of 2.5 ± 0.9 Hz, and a range of (1.1–4.1) for amblyopic eyes is ≤21 dB, while the cutoff value of minimal contrast level at mean frequencies of 13.4 ± 2.6 Hz, and a range of (6.7–18) for amblyopic eyes is ≤12 dB. Conclusion: Detection of amblyopia by CST is a noninvasive and easy procedure, which represents a promising tool to support the diagnosis of amblyopia.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 72%

Assessment of amblyopic children undergoing occlusion therapy by pattern visual evoked potentials and contrast sensitivity tests

Nada

Gohary

Azmy

et al. 2023

European Journal of Ophthalmology

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“…Hamurcu et al 25 demonstrated that P50 and N95 amplitudes were significantly lower in eyes with anisometropic amblyopia.…”

Section: Discussionmentioning

confidence: 98%

Is Fixation Preference a Potential Indicator of Macular Function in Children?

Şekeroğlu¹,

Bilgiç²,

Karakaya³

2021

tjo

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Objectives: Fixation preference testing is widely used to detect amblyopia, particularly in preverbal children. Pattern electroretinogram (pERG) is an electrophysiological test which is a sensitive indicator of macular function. The aim of this study was to investigate the relationship between fixation preference and macular function on pERG in children with strabismus. Materials and Methods: The study included 11 children with strabismus. All underwent ophthalmological examination including fixation preference by binocular fixation pattern test, best corrected visual acuity (BCVA) assessment, and pERG. Results: The mean age of the patients was 10.09±1.18 years. All patients had unilateral fixation. The mean BCVA was 0.85±0.17 in preferred and 0.48±0.19 in non-preferred eyes (p=0.003). The mean p50 amplitude was 6.07±2.06 μV in preferred and 5.29±2.20 μV in non-preferred eyes (p=0.203), and the mean N95 amplitude was 8.27±2.86 μV and 8.03±3.24 μV respectively (p=0.594). BCVA was correlated with p50 and N95 amplitudes in the non-preferred eyes (p=0.023 and p=0.014). Interocular BCVA difference was correlated with interocular P50 amplitude difference (r=0.688, p=0.019). Conclusion: Although amblyopia is typically considered a cortical phenomenon, future larger studies are needed to investigate the relationship between fixation preference and macular electrophysiological function.

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“…It is also used in the evaluation of visual function by transmitting the ganglion cell response generated by flash or pattern stimulation to the occipital cortex. While VEP wave responses are generally not affected in refractive myopia; in patients with degenerative myopia, there may be a decrease in the amplitude of the positive wave and a prolongation of the latency period in VEP due to the involvement of optic nerve and ganglion cells [11,12,13,14]. In our case, with the decrease in visual acuity; in VEP, the latency time was normal; in pattern VEP, the amplitude of the p100 wave obtained with a 120' pattern was low and the latency period was long in the right eye; no response was obtained with other patterns.…”

Section: Case Reportmentioning

confidence: 97%

A Case Report: Electrophysiological Findings in Degenerative Myopia

Başçiftçi¹

2022

AMCRCS

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We report electrophysiological findings in a patient that has degenerative myopia. The visual acuity of a 48 years old male patient was counting fingers from 0.1 with refraction (-11.00, -1.00 x115) in the right eye and 0.6 with refraction (-5.00, -1.50 x35) in the left eye. Bilateral anterior segment examination was normal however; on the fundus examination, there were atrophic scar area in the macula and pigmented degenerative areas in the inferior on the right, while there were chorioretinal atrophy and degenerative areas in the peripheric retina on the left. Normal latency response was obtained in VEP. In the right eye, a low amplitude and long latency response was obtained with the 120' pattern, but no response was obtained with the other patterns. In the left eye, there was a response to patterns shrinking to 15', the p100 wave was minimally low for age, and its latency was within normal limits. 7' pattern could not be answered. With ERG, bilateral rod b wave responses were subnormal for age, and cone b wave responses were low. Oscillatory responses were obtained bilaterally low.

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Electrophysiologic evaluation of amblyopia

Cited by 4 publications

References 18 publications

Assessment of amblyopic children undergoing occlusion therapy by pattern visual evoked potentials and contrast sensitivity tests

Assessment of amblyopic children undergoing occlusion therapy by pattern visual evoked potentials and contrast sensitivity tests

Is Fixation Preference a Potential Indicator of Macular Function in Children?

A Case Report: Electrophysiological Findings in Degenerative Myopia

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