The CPAT challenged both the aerobic and anaerobic energy supply systems, and the average V x O2 and HR were similar to reported values during firefighting simulations with incumbent firefighters.
We determined the effects of exercise on active expiration and end-expiratory lung volume (EELV) during steady-state exercise in 13 healthy subjects. We also addressed the questions of what affects active expiration during exercise. Exercise effects on EELV were determined by a He-dilution technique and verified by changes in end-expiratory esophageal pressure. We also used abdominal pressure-volume loops to determine active expiration. EELV was reduced with increasing exercise intensity. EELV was reduced significantly during even mild steady-state exercise and during heavy exercise decreased an average of 0.71 +/- 0.3 liter. Dynamic lung compliance was reduced 30-50%; EELV remained greater than closing volume. Changing the resistance to airflow (via SF6-O2 or He-O2 breathing) during steady-state exercise changed the peak gastric and esophageal pressure generation during expiration but did not alter EELV; breathing through the mouthpiece produced similar effects during exercise. EELV was significantly reduced in the supine position. With supine exercise active expiration was not elicited, and EELV remained the same as in supine rest. With CO2-driven hyperpnea (7-70 l/min), EELV remained unchanged from resting levels, whereas during exercise, at similar minute ventilation (VE) values EELV was consistently decreased. At the same VE, treadmill running caused an increase in tonic gastric pressure and greater reductions in EELV than either walking or cycling. We conclude that both the exercise stimulus and the resultant hyperpnea stimulate active expiration and a reduced FRC. This new EELV is preserved in the face of moderate changes in mechanical time constants of the lung. This reduced EELV during exercise aids inspiration by optimizing diaphragmatic length and permitting elastic recoil of the chest wall.
The interrelationships among blood lactate (La-) and plasma norepinephrine (NE) and epinephrine (Epi) were studied simultaneously with measures of ventilation (VE) and gas exchange during incremental exercise to exhaustion in nine healthy young men. We wanted to observe whether the tight coupling that exists during normoxic exercise between the concentrations of La- ([La-]) and of both NE and Epi would also be found in hypoxia (inspired O2 fraction = 0.14). In addition, we used recently advocated methods of V slope [CO2 output vs. O2 uptake (VO2)] to select the ventilatory threshold (VT) and log-log transformation of [La-] and VO2 to select the lactate threshold (LT). Peak VO2 was reduced from 4,164 +/- 184 ml/min in normoxia to 3,635 +/- 144 ml/min in hypoxia (P < 0.05). The increase in [La-] was linearly related to the increases in both NE and Epi concentrations in the normoxic and hypoxic tests (r = 0.92-0.96). Estimates of VO2 at VT were significantly greater than those at LT in both normoxia and hypoxia, but these estimates were poorly correlated (r = -0.11-0.46). VT and LT were reduced by hypoxia. Visual interpretation of the VT by examination of VE vs. VO2 and VE/VO2 vs. VO2 did not differ from the LT, but they were less than the VTs by the V-slope method (P < 0.05); yet, all were poorly correlated. The tight coupling between the increase in [La-] and the increase in plasma catecholamines might indicate a common mechanism for the increase or a causative link. VT and LT provided estimates of the general trend in the data, but the poor correlation between them questions the utility of attempting to predict one from the other.
The purpose of this study was to determine whether abdominal belts such as those prescribed to industrial workers reduced trunk muscle activity and/or increased intra-abdominal pressure (IAP). In this study, six subjects lifted loads (72.7 to 90.9 kg) both with and without wearing a weightlifter belt. In addition, further trial conditions required that subjects lifted both with the breath held or continuously expiring on lifting effort. Dynamic hand loads were recorded together with intra-abdominal pressure (IAP) and abdominal, intercostal and low back EMG. Every subject demonstrated an increase in IAP when wearing the belt during both breathing conditions: 99 mmHg with no belt; 120 mmHg wearing belt (p less than 0.0001). However, it was also found that significant increases in IAP occurred (p less than 0.017) when the breath was held versus exhaling with or without the belt. One would expect that if the belt relieved either the direct compressive load on the spine or assisted IAP to produce an extensor moment then this would be reflected in diminished extensor muscle activity. Erector spinae activity tended to be lower with the breath held suggesting a reduced load on the lumbar spine although wearing a belt did not augment this reduction. In the case studies with subjects wearing an ergogenic corset designed for use by industrial manual materials handlers, perceptions of improved trunk stability were reported. However, the muscle activity and IAP results of this study during short duration lifting tasks make it difficult to justify the prescription of abdominal belts to workers.
Muscles of the torso have been implicated to play a role in stabilization of the low back, and to assist in ventilation. This motivated an investigation to combine a load challenge to the low back with a breathing challenge, similar to that which a worker might experience when shovelling snow. Perhaps modulation of muscle activity needed to facilitate breathing may compromise the margin of safety of tissues that depend on constant muscle activity for support. Eight young healthy males dynamically lifted, and isometrically held, large loads (73-95 kg) and breathed a 10% CO2 gas mixture to elevate breathing (both with and without hand-held loads). Individual tissue forces were calculated using an anatomically detailed, dynamic model of the torso that was sensitive to individual variation by utilizing myoelectric signals, intra-abdominal pressure, ventilation rate and spine kinematics, obtained from each subject, as input. For large loads in the hands, most subjects appeared to stabilize the trunk with large muscle forces relegating the responsibility of creating lung air flow to the diaphragm. When reasonably small low-back demands were coupled with a breathing challenge and higher ventilation rates two out of eight subjects demonstrated entrainment of abdominal activity to breathing that resulted in additional cyclic low-back compressive loading of the order of 1000 N. Ergonomists should consider the additional tissue loading from physiologically demanding tasks and the related ventilation challenge, together with the tissue loads required to support external objects and maintain body posture.
Background and PurposeCognitive decline is a function of normal aging; however, the effect of age on various domains is differential. This study examined the effect of age on verbal fluency and showed how speed of processing modifies fluency performance in healthy older adults compared to younger individuals.MethodsThree age groups, 62 young (17–40 years), 30 middle-aged (41–59 years), and 38 older adults (60–78 years), were studied using the Controlled Oral Word Association Test, National Adult Reading Test, and speed-of-processing composite score. The study examined the effect of age on fluency before and after controlling for processing speed and intelligence quotient.ResultsThe young group performed better than the older group on category fluency as measured by animal category (p < .001) and on processing speed composite score (p < .001). However, the older group performed better than the young group on the National Adult Reading Test (p < .05) and on letter fluency after controlling for the decline in processing speed (p < .05). Processing speed had a significant effect on both category and letter fluency (p < .01) in older adults.ConclusionsThis study suggests that aging adversely affects some but not all cognitive domains and that age-related decline in processing speed contributes to age-related changes in fluency.
To examine the effect of postnatal development on changes in oxidative potential of fibers of specific types (I, IIa, IIb, and IIc) in the rat diaphragm, determinations of succinate dehydrogenase (SDH) activity were made using microphotometric measures of optical density. Samples of the costal region of the diaphragm were extracted from 56 male Wistar rats ranging in age from 8 to 85 days and subgrouped into seven developmental periods (1, 2, 3, 4, 6, 9, and 12 wk). For type I fibers, increases of 17% (P less than 0.05) in SDH activity occurred during 2nd wk, remained elevated through 4th wk, and increased further (P less than 0.05) to 137% of 1-wk values by the end of 6th wk. No further increases were noted between 6 and 12 wk. A similar maturational trend was evident for type IIa fibers, although SDH activities remained higher throughout development when compared with type I fibers. In contrast, SDH in type IIb fibers, although increasing by 14% during the first two measurement weeks (P less than 0.05), declined from 6 to 9 wk before ultimately reaching a value similar to 3 wk. SDH activity was also assessed in a typical slow- (soleus) and fast-twitch (extensor digitorum longus, EDL) muscle of the hindlimb to contrast their development with that of the diaphragm. Generally, SDH in type I and IIa fibers was approximately 40 and 20% higher, respectively, in the diaphragm than in matched fiber types in the other muscles throughout development (diaphragm greater than EDL greater than soleus).(ABSTRACT TRUNCATED AT 250 WORDS)
To investigate the role of high-intensity intermittent exercise on adaptations in blood volume and selected hematological measures, four male subjects aged 19-23 yr [peak O2 consumption (VO2max) = 53 ml X min-1 X kg-1] performed supramaximal (120% VO2max) cycle exercise on 3 consecutive days. Each exercise session consisted of intermittent work performed as bouts of 1-min work to 4-min rest until fatigue or until a maximum of 24 repetitions had been completed. Measurements on blood samples were made before the exercise period and 24 h after the last exercise session. Plasma volume (PV) estimated using 131I-human serum albumin increased by 11.6% (3,504 vs. 3,912 ml; P less than 0.05). Total blood volume (TBV) based on PV and hematocrit (Hct) values increased by 4.5% (5,798 vs. 6,059 ml; P less than 0.05), whereas red cell volume (RCV) decreased by 6.4% (2,294 vs. 2,147 ml; P less than 0.05). Measurements of hematological indices indicated significant reductions (P less than 0.05) in whole-blood Hct (39.7 vs. 35.5%), hemoglobin concentration (15.5 vs. 13.9 g/100 ml), hemoglobin content (897 vs. 839 g), and red blood cell count (5.15 vs. 4.55 X 10(6) X mm-3). The findings of this study suggest that exercise intensity is a major factor in promoting exercise-induced hypervolemia and that rapid elevations in PV can be induced early in training.
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