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The article presents the results of research in the field of early diagnosis and dynamic monitoring of immunological changes in the human body in the course of COVID-19 coronavirus infection and after the disease. The article presents the results of laboratory tests for the presence of IgG antibodies to the SARS-CoV-2 coronavirus in 2112 patients living in 5 regions of the Russian Federation. The aim of this study was to evaluate the dynamics of IgG class antibodies to SARS-CoV-2 coronavirus (COVID-19) in the blood of patients who had a new coronavirus infection. We found that there were no significant changes in the level of IgG antibodies to the SARS-CoV-2 coronavirus from the 14th day of illness to the 3rd month of observation from the moment of the first symptoms of the disease. Starting from the 4th month of observation, the level of antibodies decreased in both groups by multiples in relation to the maximum values, decreasing by the 6th month of observation to the values of the control group. The results of the study can be used to develop an optimal diagnostic, therapeutic and preventive algorithm for reducing infection in the population and the number of severe cases of the disease.