Six indanone-based chalcones were successfully synthesised from 1-indanone and 4-benzaldehyde derivatives via Claisen-Schmidt condensation reaction. The synthesised indanone-based chalcones were characterised by CHN elemental analysis, FTIR spectroscopy and NMR spectroscopy to determine their structures. Vasodilation studies indicated compounds 1b1 and 1-OH showed good vasodilation properties with R max value of 38.34 ± 8.90% and 96.68 ±14.77%, respectively. Compound with hydroxyl group shows better effect to the relaxation of the aortic rings.
Das 3‐allylsubstituierte Acetylaceton liegt in einem Keto‐Enol‐Tautomeriegleichgewicht vor und reagiert in wäßriger Ammoniaklösung mit Metallnitraten unter Bildung der Komplexe (Ia), (IIa) und (IIIa).
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