In this study, two methods have been applied to the extraction of parabens from aqueous solution these are ionic liquid based aqueous two-phase extraction (IL-ATPS) and ionic liquid based aqueous two-phase extraction in the presence of b-cyclodextrin (b-CD) as the modifier (IL-bCD-ATPS). The IL-bCD-ATPS method consists of 1-butyl-3-methylimidazolium chloride, [C 4 mim][Cl] and b-CD. It is a new, green and simple extraction technique coupled with reversed-phase high performance liquid chromatography (RP-HPLC) that was applied to optimize conditions for the phase separation of parabens in water samples.The IL-bCD-ATPS method shows higher losses for water content compared to the IL-ATPS method resulting in a higher preconcentration factor and a higher distribution coefficient. A lower limit of detection of parabens in water samples was demonstrated by the IL-bCD-ATPS method. To conclude, the IL-bCD-ATPS method is superior to the IL-ATPS method for the determination of parabens in water samples. It is an economically viable approach when using b-CD because it improves the performance of the ATPS method dramatically. In addition, this chemical is cheap and non-toxic to the environment.
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