1 NO-and prostaglandin-independent, endothelium-dependent vasodilator responses to bradykinin are attributed to release of a hyperpolarizing factor. Therefore, the contribution of K+ channels to the renal vasodilator effect of bradykinin was examined in rat perfused kidneys that were preconstricted with phenylephrine and treated with N -nitro-L-arginine (L-NOARG) and indomethacin to inhibit NO and prostaglandin synthesis.
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