Sustained intestinal delivery of drugs such as 5-fluorouracil (choice for colon carcinomas) and insulin (for diabetes mellitus) seems to be a feasible alternative to injection therapy. For successful therapy, the drug should be delivered at proper sites (here, the intestine) for long duration, for producing maximum pharmacological activity. We have attempted to develop a formulation that can bypass the acidity of the stomach and release the loaded drug for long periods into the intestine by using the bioadhesiveness of polyacrylic acid, alginate, and chitosan. Bromothymol blue was taken as a model drug. The formulation exhibited bioadhesive property and released the drug for an eight-day period in vitro.
Electro discharge machining (EDM) is an unconventional machining process that uses spark energy to remove material from the workpiece. EDM process is extensively being used in die/mould making industries, automobile industry, aerospace industry etc. for generating complex and intricate shape on hard material.
Numbers of research works have been carried out using EDM process in order to improve the performance. Further, different variant of EDM process like dry EDM, orbital EDM, powder mixed EDM, ultrasonic assisted EDM and rotary EDM etc. have also been studied. Rotary EDM process is very promising process that helps to improve surface finish, overcut as well as out of roundness. In the present paper, a extensive review has been presented on rotary EDM process. Significance of several input parameters has been observed on output characteristics like overcut and out of roundness.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.