A prospective survey offecal, urinary tract, and environmental colonization by Providencia stuartii in two wards was undertaken over a 5-month period. Eight of 53 male patients and 2 of 89 female patients were colonized with the endemic serotype 0:63. Two patterns of colonization were found on the male ward. Two patients had persistent urinary tract colonization with no detectable fecal carriage. The other patients had fecal carriage, in some cases persistent, with intermittent urinary tract colonization. The ward environment was in general not contaminated. This study demonstrates that fecal colonization of patients by P. stuartii may be an important and previously underestimated nosocomial reservoir.
The sensitivities of 80 gentamicin-resistant gram-negative bacilli to cefotaxime, cefuroxime, cefoxitin, cefamandole, cefazolin, tobramycin, netilmicin and amikacin were determined. Amikacin was the most active amino-glycoside. However, the percentage sensitivity to cefotaxime of most of the species was higher than, or equal to any of the other antibiotics tested. Cefotaxime was particulary active against Providencia spp., Serratia spp., Klebsiella spp., and Pseudomonas maltophilia, being 16 to 256 times more active than the next best cephalosporin or cephamycin. Clinical trials of cefotaxime are now required.
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