AIM
To determine the prevalence of poly-pharmacy and pattern of associated drug- drug interactions among CKD patients.
OBJECTIVE
To assess the various classes of drugs prescribed among CKD patients. To assess the drug – drug interactions. To assess the prevalence of poly-pharmacy and the pattern of associated comorbidities among CKD patients.
METHOD
A descriptive prospective study of 6 months duration that was carried out to review the medical case records of adult CKD patients attending GGH tertiary care hospital.
CONCLUSION
The prevalence of polypharmacy is predominantly high among CKD patients. The burden of polypharmacy and the pattern of associated comorbidities can result in increase in the risk of drug related problems such as drug-drug interactions, the need is to minimize the number of prescribed medications for CKD patients in order to reduce the morbidity, mortality and length of the hospital stay.
This study was conducted to know the relation of non-alcoholic fatty liver disease (non-alcoholic steatohepatitis & cirrhosis) with metabolic syndrome. MATERIAL AND METHODS: 60 cases were selected. Out of them 30 were non-alcoholic steatohepatitis and 30 cirrhosis along with 30 healthy controls. Parameters of metabolic syndrome and liver function which are waist circumference, blood pressure, fasting plasma glucose, total triglycerides, high density lipo-protein cholesterol, total bilirubin, alanine amino transferase, alkaline phosphotase, total proteins and albumin were measured. STATISTICAL ANALYSIS: All values were expressed as mean ± SD. The results obtained were analyzed statistically using the unpaired student 't'test to evaluate the significance of differences between the mean values. RESULTS: The values of waist circumference, fasting plasma glucose, systolic blood pressure, total triglycerides, total bilirubin, alanine-amino-transferase and alkaline phosphotase were raised in non-alcoholic steatohepatitis and cirrhosis patients. The level of high density lipoprotein cholesterol was decreased in non-alcoholic steatohepatitis and cirrhosis patients.
The present study was conducted to know the relation of myocardial infarction with its risk factors and to prevent future cardiac events. MATERIAL AND METHODS: 60 cases of myocardial infarction were selected along with 60 age and sex matched healthy controls. Body mass index, blood pressure, fasting plasma glucose and lipid profile were measured. STATISTICAL ANALYSIS: All values were expressed as Mean +/-SD. The results obtained were analyzed statistically using the unpaired student 't' test to evaluate the significance of difference between the mean values. RESULTS: The values of body mass index, fasting plasma glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, total triglycerides and low density lipoprotein cholesterol were increased whereas high density lipoprotein cholesterol was decreased in the patients of myocardial infarction. CONCLUSION: On the basis of our results, it may be concluded that risk factors increase incidence of myocardial infarction.
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