After statistical analysis of biochemical parameters in 60 patients with acute leukaemia, it was concluded that most prominent alterations were elevated values of serum lactate-dehydrogenase, uric acid and calcaemia. In patients with acute myeloid leukaemia, prothrombin time and partial thromboplastin time were significantly prolonged, and in patients with acute lymphocytic leukaemia serum immunoglobuline levels were significantly lower. Biochemical alterations may produce some implications for the general state of the patient, as well as for the clinical course of the disease, its complications and outcome, with possible influence on the effect of therapy.
We report here a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) in chronic phase in whom the alkaline phosphatase activity of neutrophils in the peripheral blood was low while at the same time the alkaline phosphatase content of neutrophils present in the urine was elevated. This observation provides independent clinical support for the recent experimental finding that an extrinsic factor (granulocyte colony-stimulating factor) controls alkaline phosphatase expression in human neutrophils.
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