Oxidative electrochemical pretreatment of carbon fibers greatly Improves their sensitivity for In vivo electrochemical detection of catecholamine species. It Is shown that the extent of the anodic potential excursion In the pretreatment Is a major factor In both the sensitivity and the response time of the resulting fiber electrode. The high sensitivity for neurotransmitter species such as dopamine appears mainly due to adsorption on the oxidized carbon fiber surface states. Practical protocols for fiber electrodes to be used In In vivo brain studies are evaluated.

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