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Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles with a single-step nano-precipitation method, leading to formation of ART/ mPEG-PCL micelles. mPEG-PCL copolymers was characterized in vitro by HNMR, FTIR and DSC techniques. Copolymers with artemisinin were self-assembled into micelles in aqueous solution. The consequential micelles were further characterized by various techniques such as DLS and AFM. Results: The results exhibited the successful formation of spherical artemisinin-loaded micelles. The artemisinin-loaded micelles showed high loading efficiency. The encapsulation efficiency of artemisinin was 63±2.31%. In vitro release of artemisinin from artemisinin-entrapped micelles followed remarkably sustained release profile. Conclusion: The results indicated that the successful formulation of artemisinin loaded mPEG-PCL micelles can improve the drug delivery of artemisinin. The results showed that nanomicelles can be promising drug delivery systems for sustaining release of artemisinin.

Efficient Electrosynthesis of 1,2,4-Triazino[3,4-b]-1,3,4-thiadiazine Derivatives. -Electrolysis of a mixture of catechols and the triazine (II) is studied in aqueous solution using cyclic voltammetry and controlled-potential coulometry. It results in isolation of title compounds (III) and (VI), which may be of pharmaceutical interest. -(FOTOUHI*, L.; MOSAVI, M.; HERAVI, M. M.; NEMATOLLAHI, D.; Tetrahedron Lett. 47 (2006) 48, 8553-8557; Dep. Chem., Fac. Sci., Alzahra Univ., Vanak, Tehran, Iran; Eng.) -Mais 12-171