Immunologic infertility can be treated by IVF with very good results. The most important group are women with AZA, in whom IVF ICSI without any delay is recommended.
Brown‐adipose tissue mitochondria of hamster and rat contain phosphoenolpyruvate carboxykinase (EC 4.1.1.32). In the presence of ketoglutarate and malate, phosphoenolpyruvate is formed and exported forms mitochondria. Phosphoenolpyruvate formation is inhibited by 1,2,3‐benzenetricarboxylate. It is proposed that phosphoenolpyruvate carboxykinase together with pyruvate carboxylase and pyruvate kinase forms a phosphoenolpyruvate shuttle through which energy produced by the Krebs cycle in mitochondria may be exported to cytosol.
Poly-(hydroxyethylmethacrylate) gel contact lenses saturated with a 0.1% solution of IDU containing 5-iodo-2’-desoxyuridine-3H were applied onto normal rabbit eyes and after scarification of the epithelium, wounding of the stroma and experimental herpetic keratitis, IDU was easily released from the gel. The intraocular penetration was 2–3 times higher in the eyes with corneal defects as compared with intact eyes. The results indicate that hydrophilic contact lens can be used as a carrier of IDU in the treatment of herpetic keratitis and iritis.
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