Use of Hydrophilic Contact Lens for Application of IDU. Study on Rabbits with Artificial Cornea Lesions and Herpetic Keratitis

Abstract

Poly-(hydroxyethylmethacrylate) gel contact lenses saturated with a 0.1% solution of IDU containing 5-iodo-2’-desoxyuridine-³H were applied onto normal rabbit eyes and after scarification of the epithelium, wounding of the stroma and experimental herpetic keratitis, IDU was easily released from the gel. The intraocular penetration was 2–3 times higher in the eyes with corneal defects as compared with intact eyes. The results indicate that hydrophilic contact lens can be used as a carrier of IDU in the treatment of herpetic keratitis and iritis.

Tetracycline: Release from Hydrophilic Gel Contact Lens and Intraocular Penetration

“…Particular attention has been paid to the application of contact lenses pre soaked with the above-mentioned drugs to intact rabbit eyes, after abrasion of the epithelium and following chemical burns or corneal inflammation [Brettschneider et a i, 1975;K rejcI et al, 1976;P raus et a!., 1976. 1977, K r e jc I [1971] has reported on the favourable clinical experience with the application of antibiotics by means of hydrophilic gel contact lenses.…”