Cultured epithelial autografts offer an exciting approach to cover extensive skin wounds. The main problem of this method is mechanical instability during the first weeks after grafting. There is evidence that the shortcomings of autografting cultured keratinocytes result from the lack of a mature and functional dermo-epidermal junction. This article summarizes the current knowledge regarding the de novo formation of the dermo-epidermal junction and the dynamics of "take" and stabilization of cultured epithelial autografts. Future strategies are discussed of how to improve and accelerate the process conferring definitive stabilization of cultured epithelial autografts including the potential therapeutic use of transglutaminase as well as cocultivation of a dermo-epidermal equivalent in order to facilitate a permanent skin replacement.
We report on a 12-year-old girl who underwent laparoscopic excision of a left-sided hydrosalpinx. She presented with recurrent lower abdominal pain 8 years after appendectomy and resection of the left ovary. Sonography revealed a large cystic, tubular mass cranial and to the left of the urinary bladder. Laparoscopy demonstrated a left-sided hydrosalpinx which was resected endoscopically using a stapler.
Scar formation and fibrosis often cause devastating disabilities in children suffering severe burn injury. In contrast to the child, the fetus has the ability to heal skin injury without scar formation, and instead with regeneration of epithelial and mesenchymal tissues and restoration of normal skin architecture. In this paper we review those unique features of the fetus and fetal wound healing that may contribute to the scarless repair process. It is hoped that an understanding of these remarkable reparative capabilities may lead to the development of new wound healing therapies that reduce or prevent scar formation and fibrosis in the management of children with burns.
Verschluckte, im Ösophagus stecken gebliebene, Knopfbatterien müssen notfallmäßig entfernt werden, da sie trotz rascher Entfernung in kürzester Zeit durch verschiedene Mechanismen zu tiefen Verletzungen der Mukosa führen können. Dies wird anhand eines Fallbeispiels eines 2-jährigen Mädchens demonstriert, das nach rascher, unproblematischer endoskopischer Entfernung einer Knopfbatterie aus dem Ösophagus und einem zunächst guten Verlauf eine ösophagotracheale Fistel entwickelte Ka suis ti ken S. Bött cher-Ha ber zeth · D. We ber · M. Meu li · P. Sa cher · Kin der spi tal Zü rich
Öso pha gotra chea le Fis telHer vor ge ru fen durch eine im Öso pha gus ste cken ge blie be ne Knopf bat te rie Notfall + Rettungsmedizin 2005 · 8:342-345
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