In the manufacture of ophthalmic medicinal films, special attention should be paid to the choice of a film-forming substance, since both the shape of the future film and its medicinal properties as a whole depend on it. This article provides a laboratory analysis with a comparative assessment of the optimal concentrations of two film-forming substances, polyvinyl alcohol and gelatin. Most of the presented film formers have a number of disadvantages, such as thickness, insufficient strength and elasticity, heterogeneity, formation of cracks and creases. One of the requirements for ophthalmic medicinal films is the smoothness of the surface and the absence of sharp corners. Based on the foregoing, we set the goal of the study - to conduct a laboratory test of film-forming substances for the manufacture of ophthalmic medicinal films. An analysis of domestic and foreign works gave reason to use polyvinyl alcohol and gelatin as the basis for ophthalmic medicinal films. As a result of the study, we have established the optimal concentrations of film-forming substances (polyvinyl alcohol and gelatin) that meet the existing requirements. The optimal concentration of the gelatin solution was the ratio of 1:7. The addition of the plasticizer glycerol to gelatinin the manufacture of ophthalmic medicinal films is mandatory. The optimal concentration of the solution of polyvinyl alcohol was the ratio of 1:15. Films from both film formers did not lose their shape, did not form cracks or breaks when introduced into the conjunctival sac. No irritant effect was observed. Laying the films did not cause difficulties. Forms of gelatin completely dissolved in the eye in 40 minutes, of polyvinyl alcohol - in 90 minutes.
An important step in the manufacture of ophthalmic medicinal films is the method of applying the active substance to the base of the film former. As a result of the analysis of available methods, it is necessary to choose a method in which the prolonged action of medicinal substances remains the same, and the molecular structure of the active component does not change. A number of researchers suggest adding an active component to a film former immediately before film production. Some developers apply active ingredients to a ready-made base. Based on the foregoing, we set a goal - to test methods for applying a biostimulator from the brain tissue of cattle with the addition of silver nanoparticles to a base of film-forming substances. As laboratory models for testing the methods of applying the active substance to the film-forming base, we chose polyvinyl alcohol in a ratio of 1/15 with distilled water and gelatin in a ratio of 1/7 with distilled water. To prepare the active substance for its introduction into the film-forming agent, NaCl solution was added with a micropipette to the biostimulator from the brain tissue of cattle with the addition of silver nanoparticles and gently but thoroughly mixed. To determine the dissolution rate of the eye medicinal films obtained as a result of the experiment, the obtained samples were placed on the surface of the cornea of laboratory animals. 10 giant rabbits and two outbred dogs were chosen as experimental animals. As a result of the study, we found that the preferred method for applying a biostimulant from the brain tissue of cattle with the addition of silver nanoparticles to the base of film-forming substances (polyvinyl alcohol and gelatin) is the introduction of the active substance into the film-forming agent immediately before the production of films. Forms based on gelatin completely dissolved in the eyes of the subjects in 45 minutes, from polyvinyl alcohol - in 95 minutes.
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