Safety measures are required for spherical gas holders to prevent them from malfunctioning even after a large earthquake. In this study, considering the strong nonlinearity of the ground and damage to the pile during an earthquake, a three-dimensional seismic response analysis of the holder–pile–ground interaction system was conducted for an actual gas holder on the soft ground consisting of alternating layers of sand and clay. In the analysis, the seismic response of the structure to strong ground motions of different durations with the same acceleration response spectrum was verified. The results show that the piles were relatively effective in controlling the settlement when the duration of the earthquake motion was long. This is because the axial force acting on the pile increased due to the redistribution of the holder load caused by the lowering of the effective confining pressure of the sand and clay layers during the earthquake, which increased the bearing capacity of the pile. In contrast, when the duration of the seismic motion was short, the piles had little effect on the reduction in the settlement because the maximum acceleration was higher than that in the former case, and the piles immediately lost their support function.
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