A combination of dihydrostreptomycin sulphate (250 mg/ml) and penicillin G procaine (200,000 iu/ml) was used to treat contagious caprine pleuropneumonia caused by F38 strain of mycoplasma. A single dose of either 20, 30, 40 or 50 mg/kg body weight of the dihydrostreptomycin sulphate led to the recovery of the treated goats. The recovered goats did not transmit CCPP to susceptible goats housed with them for 2 months. The goats which recovered were found to be solidly immune to an in-contact challenge in which all the control goats died of CCPP. The treated and recovered goats were found not to be carriers of the organism.
Goats on two zero grazed farms carrying 1621 animals with a history of contagious caprine pleuropneumonia were subjected to a vaccine trial with an inactivated mycoplasma F38 vaccine. The results indicated that the vaccine produced an immune response, that it was very effective in reducing morbidity and mortality rates, and that a booster dose one month after the first dose of vaccine gave extra protection.
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