Purpose To apply wavelet analysis to investigate the sympathetic modulation upon intraocular pressure(IOP)of the cold pressure test
Methods In an autonomic dedicated lab continuous and simultaneous recording of(IOP) with Pascal(DCT) and arterial blood pressure(BP) were made in 11 healthy individuals,of both sexes,in basal conditions and during 1minute of cold‐pressure test(CPT).The tests were in the morning period and in the 24h previous individuals were told not to smoke and to avoid xanthines or other stimulants ingestion. Individuals under medication or with other pathology that could affect the autonomic nervous system were excluded. Data analysis of IOP and systolicBP (SBP) in the time‐scale domain with wavelets(DB12)was performed, for both variables, during the last minute prior to test and during one minute upon test. In this last case,periods of 10s where individually analysed and the period with the largest value was the chosen for statist analysis using t‐Student test, Welch corrected(Ducla‐Soares et al, 2007).LFIOP and LFSBP were calculated and differences between basal and CPT values were considered significant where p<0.05. Data were expressed as mean±SEM., and for LF mmHg2
Results Data refer to 6 male and 5 female with a mean age of 49[40‐70] On CPT, a sympathetic challenging manoeuvre, an increase of SBP was observed. Wavelet analysis of both signals showed a significant increase of LFIOP and LFSBP from 0.13±0.15 and 8.66±1.51 to 0.37±0.26 mmHg2 and 18.7±4.5mmHg2, respectively, and a not significant change in IOP 17.0±2.6 to18.0±1.5
Conclusion Our data show a sympathetic signature on IOP correlated with that observed in BP. We show that wavelets are a suitable tool for the evaluation of sympathetic signature on short periods of IOP recorded by DCT
Purpose: To evaluate the reproducibility of Spectralis spectral domain-OCT segmented ganglion cell layer (GCL) and macular retinal nerve fiber layer (mRNFL) measurements in a healthy children population. Methods: An observational, cross-sectional study was carried out on 79 children to measure the intraobserver reproducibility and the repeatability between a novel and an experienced operator of the segmented macular GCL and mRNFL. Interobserver and intraobserver reproducibility were defined by the intraclass correlation coefficient (ICC) and coefficients of variation (COV). Kruskal–Wallis test was used to determine statistical significance in the COV of three age groups children (younger than 6 years, between 6 and 12, and older than 12 years old). Results: The results from the intraoperator GCL thickness analysis were highly reproducible (COV < 6%) and reliable (ICCs > 0.81). When the measurements were compared between a novel and an experienced examiner lower ICCs and higher COV were found. COVs ranged from 1.85% (total volume area) to 5.57% at the central ETDRS subfield while the ICC vary from 0.632 (outer inferior) to 0.832 (inner inferior). The repeatability and reproducibility of the mRNFL thickness were lower, with ICCs ranging from 0.428 to 0.872 in the interobserver analysis and from 0.897 to 0.346 in the interobserver one. Conclusion: In the present study, we establish substantial reliability of the GCL thickness in children with Spectralis® SD-OCT in all the sectors, albeit lower than the reported in the literature with other SD-OCTs and in adults. The reproducibility and repeatability of the mRNFL were significantly lower. We were unable to find consistent statistical significant differences between the COV of the three age groups.
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