The management of diabetic foot ulceration has a significant economic impact on the Irish healthcare budget. Treatment should therefore be focused on primary prevention through specialised foot clinics and a multidisciplinary team approach to reduce this economic burden.
Summary:We report four cases of Bartter's syndrome in two consecutive generations of an Irish family. Diagnoses were made on the basis of characteristic clinical features, blood and urine biochemistry with additional evidence from renal biopsy in one case. The aetiology, treatment and inheritance of the syndrome are discussed.
Three cases of profound hypothyroidism, 2 of whom lapsed into myxoedema coma are reported. All 3 cases presented over a 5 week period. Modern management, especially the use of intensive care, has improved the outcome. All 3 cases survived. Treated hypothyroid patients frequently discontinue their medicines and constitute the majority of patients presenting in myxoedema coma. It is vital that the patient and their families are made aware that treatment must be life-long. Hypothalamic-pituitary dynamic studies with thyrotrophin-releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH) were also performed and are reported.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.