HCG Stimulation Test in Prepubertal Boys with Cryptorchidism, in Bilateral Anorchia and in Male Pseudohermaphroditism

Rivarola, M A; Bergadá, C; Cullen, M. J.

doi:10.1210/jcem-31-5-526

Cited by 91 publications

(35 citation statements)

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“…No increase in serum FSH or gonadotropins provided a means to quantify FSH and LH was observed after the 7-day course of clomiphene LH in blood and easily distinguish between elevated and administration in all gonadotropin-deficient subjects normal levels, it remained inadequate to quantitatively studied; these observations are in agreement with earlier (32). Moreover, similar treatment with HCG in some prepubertal males increased levels of plasma testosterone into the range of normal men (33,34). However, chronic HCG treatment in four out of six hyposmic patients reported by Bardin et al (17) failed to elicit either a normal adult level of plasma testosterone or clinical evidence of masculinization.…”

Section: Resultssupporting

confidence: 77%

Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.

Weinstein

Reitz²

1974

J. Clin. Invest.

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A B S T R A C T An isolated deficiency of pituitary gonadotropins was demonstrated in six 46 XY males, 22 to 36 years of age, with and without anosmia. Undetectable or low levels of serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) clearly separated hypogonadotropic from normal adult males. Chronic (8-12 wk) administration of clomiphene citrate caused no increase in serum FSH or LH in gonadotropin-deficient subjects. However, the administration of synthetic luteinizing hormone releasing factor (LRF) resulted in the appearance of serum LH and, to a lesser degree, serum FSH in three subjects tested. While levels of plasma testosterone were significantly lower in gonadotropin-deficient subjects, plasma androstenedione and dehydroepiandrosterone were in a range similar to that of age-matched normal men. Treatment with human chorionic gonadotropin (HCG) increased levels of plasma testosterone to normal adult male values in all gonadotropin-deficient subjects. Cessation of treatment with HCG resulted in the return of plasma testosterone to low, pretreatment levels. That HCG therapy with resultant normal levels of plasma testosterone may somehow stimulate endogenous gonadotropin secretion in gonadotropin-deficient subjects was not evident. The adult male levels of serum FSH and LH after LRF, and plasma testosterone after HCG, confirm pituitary and Leydig cell responsiveness in these subjects.

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Section: Resultssupporting

confidence: 77%

Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.

Weinstein

Reitz²

1974

J. Clin. Invest.

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“…Before the age of 12 years, the peak plasma testosterone response to HCG stimulation was within the normal range in Klinefelter's syndrome [9]. Also, cryptorchid prepubertal boys showed similar re sponses [14], In our case, basal plasma levels of gonado tropins and testosterone were within normal limits. Tes tosterone response to HCG was within the normal range.…”

Section: Discussionsupporting

confidence: 66%

Klinefelter’s Syndrome Associated with Unilateral Cryptorchidism in Childhood

Sasagawa

Yamaguchi²,

Shiraiwa³

et al. 1991

Urol Int

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“…In fact, basal concen- tration and urinary excretion of testosterone cannot be related to gonadal func tion at this stage of pubertal development, since in prepubertal subjects, large amounts of testosterone come from adrenal source. Rivarola et al (6) studied the response of plasma testosterone in prepubertal cryptorchid boys after 5 days of daily injections of HCG (800-5,000 lU/day). The magnitude of the testos terone increment found by these authors is comparable to that observed in the pesent study after 6 weeks of HCG treatment with a total dose of 23,000 IU.…”

Section: Discussionmentioning

confidence: 99%

Plasma Testosterone in Prepubertal Cryptorchid Boys under Long-Term HCG Therapy

Attanasio¹,

Rager²,

Gupta³

1976

Horm Res

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Plasma testosterone concentrations were determined before and after 6 weeks of human chorionic gonadotropin treatment in 36 prepubertal boys with bilateral or unilateral cryptorchidism. Mean ± SD basal and post-treatment values (ng/l00 ml) in the bilateral group were: treatment successful (n = 14): 32 ± 19 and 302 ± 49, treatment unsuccessful (n = 12): 20 ± 15 and 176 ± 73. The figures for the unilateral group were: treatment successful (n = 6): 23 ± 9 and 244 ± 41, treatment unsuccessful (n = 5): 22 ± 11 and 264 ± 102. In the bilateral group significant differences in the T response emerged when successfully treated boys were compared to unsuccessfully treated ones. It is concluded that Leydig cell function may be impaired in some cases of cryptorchidism.

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HCG Stimulation Test in Prepubertal Boys with Cryptorchidism, in Bilateral Anorchia and in Male Pseudohermaphroditism

Cited by 91 publications

References 0 publications

Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.

Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.

Klinefelter’s Syndrome Associated with Unilateral Cryptorchidism in Childhood

Plasma Testosterone in Prepubertal Cryptorchid Boys under Long-Term HCG Therapy

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