A 1:1 salt of carvedilol (CVD), an anti-hypertensive drug, with DL-mandelic acid (DL-MA) was crystallized from ethanol and the structure was characterized by X-ray single-crystal diffraction, revealing salt formation by transfer of an acidic proton from the COOH group of MA to the aliphatic (acyclic) secondary amino NH group of CVD. The crystal structure is triclinic, with a P-1 space group and unit cell parameters a = 9.8416(5) Å, b = 11.4689(5) Å, c = 14.0746(7) Å, α = 108.595(8), β = 95.182(7), γ = 107.323(8), V = 1406.95(15) Å3, and Z = 2. The asymmetric unit contained one protonated CVD and one MA anion, linked via an N+–H∙∙∙O¯ strong hydrogen bond and a ratio of 1:1. As previously reported, the thermal, spectroscopic, and powder X-ray diffraction properties of the salt of CVD with DL-MA (CVD_DL-MA) differed from CVD alone. The intrinsic dissolution rate of CVD_DL-MA was about 10.7 times faster than CVD alone in a pH 6.8 buffer.
Magnetic properties
Magnetic properties D 9000Magnetism of CaRuO 3 Crystal. -Single crystals of the title compound are grown by the flux method using CaCl 2 as a flux. The compound is characterized by magnetic measurements and Moessbauer spectroscopy on a Fe 0.01 O 3 crystal. No magnetic order exists at temperatures down to 15 K. However, the magnetization curve of the crystal shows peculiar behavior at 1.7 and 5 K, suggesting the existence of magnetic order at very low temperature. -(KORIYAMA, A.; ISHIZAKI, M.; OZAWA, T. C.; TANIGUCHI, T.; NAGATA*, Y.; SAMATA, H.; KOBAYASHI, Y.; NORO, Y.; J.
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