Human skin is a remarkable organ that sustains insult and injury throughout life. The ability of skin to expeditiously repair wounds is paramount to survival. With an aging global population, coupled with a rise in the prevalence of conditions such as diabetes, chronic wounds represent a significant biomedical burden. Mesenchymal stem cells (MSC), a progenitor cell population of the mesoderm lineage, have been shown to be significant mediators in inflammatory environments. Preclinical studies of MSC in various animal wound healing models point towards a putative therapy. This review examines the body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies and also the possible mechanisms controlling its efficacy. The delivery of a cellular therapy to the masses presents many challenges from a safety, ethical, and regulatory point of view. Some of the issues surrounding the introduction of MSC as a medicinal product are also delineated in this review.

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INTRODUCTION:The nose is particularly exposed to facial burn accidents due to its situation and is usually accompanied with deformities of other organs of the face. The aim of our study is the discussion of how rhinoplasty can be done safely in these victims with pleasing outcome. MATERIAL AND METHOD: We present 10 cases, with complete or subtotal nasal burn. Classic aesthetic rhinoplasty operations were performed to create a better appearance and correct any internal or external deviations. Standard view photographs were taken before and after operation. Patients and surgeon satisfaction were recorded. RESULTS: Ten patients (9 F, 1 M) whose noses had burn scar or has been grafted or reconstructed, were operated. Patient age ranged from 18 to 46. We performed the classic rhinoplasty operation to repair any respiratory or aesthetic problems due to shrinkage of soft tissues. These procedures are carried out under severely burned skins, or previously grafted and reconstructed noses. Cases were followed for about a 9 months period. The cosmetic results, discussed by 3 surgeons and subjective patient feelings, were considered satisfactory in 90% of cases. CONCLUSIONS: Nasal skin flaps should be thick enough to prevent probable necrosis in distal part, and no skin thinning procedure should be done. The other problem is the rigid covering grafted or scarred skin, which is less pliable to take the form of the modified osteocartiagenous skeleton. Rhinoplasty seems to complete and improve the results of the standard surgical approach in burned face.