Background Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention efforts. We aimed to evaluate the age-specific prevalence of anal HPV, HSIL, and their combination, in men, stratified by HIV status and sexuality.
MethodsWe did a systematic review for studies on anal HPV infection in men and a pooled analysis of individuallevel data from eligible studies across four groups: HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive men who have sex with women (MSW), and HIV-negative MSW. Studies were required to inform on type-specific HPV infection (at least HPV16), detected by use of a PCR-based test from anal swabs, HIV status, sexuality (MSM, including those who have sex with men only or also with women, or MSW), and age. Authors of eligible studies with a sample size of 200 participants or more were invited to share deidentified individual-level data on the above four variables. Authors of studies including 40 or more HIV-positive MSW or 40 or more men from Africa (irrespective of HIV status and sexuality) were also invited to share these data. Pooled estimates of anal high-risk HPV (HR-HPV, including HPV16,
Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain. Rev Esp Enferm Dig 2017;109(4):242-249. DOI: 10.17235/reed.2017109(4):242-249. DOI: 10.17235/reed. .4274/2016 Received: 26-02-201626-02- Accepted: 22-12-2016
ABSTRACT
Background and aims:Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain).Method: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors.Results: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma.Conclusions: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.
Hernia interna a través del hiato de Winslow asociada a rotación incompleta del intestino medio Palabras clave: Hiato de Winslow. Herniación interna. Rotación intestinal imcompleta.
There is substantial evidence that use of an intrauterine device (IUD) reduces the risk of endometrial cancer. Little is known about the potential effects of an IUD on the risk of developing cervical cancer or cervical human papillomavirus (HPV) infection. A number of studies have addressed the concern that these devices could cause cervical cancer, but the results have been inconclusive.This study used pooled data from 2 large epidemiologic studies that explored the potential effects of IUD use on the risk of cervical HPV infection and the risk of developing cervical cancer. The 2 studies were conducted by the International Agency for Research on Cancer and Institut Català d'Oncologia research program on HPV and cervical cancer. Data from 1 study were obtained from 10 case-control studies of cervical cancer conducted in 8 countries; the other study included data for 16 HPV prevalence surveys from 14 countries for women in the general population. The final pooled analysis included 2205 women with cervical cancer and 2214 matched control women without cervical cancer from the case-control studies, and 15,272 healthy women from the HPV surveys. Personal interviews with participants provided information on potential risk factors for cervical cancer, including IUD use and duration of polymerase chain reaction-based assays, which were used to detect HPV DNA. Multivariate unconditional logistic regression analysis was used Cancer
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