Probiotic bacteria is one of the biological control. It had a role inhibiting or killing pathogenic microorganisms. In addition, it also played a role in improving water quality as in fish maintenance media. The basic principle of probiotics was the utilization of the ability of microorganisms to increase absorption in the digestive tract of fish. Probiotic bacteria were able to produce antimicrobial compounds such as lactic acid, hydrogen peroxide, and bacteriocin. These compounds were antimicrobial and antibiotic that can suppress the growth of pathogenic bacteria. The purpose of this study is to isolation candidate probiotic bacteria from the mangrove tourism area in Klawalu, Sorong City, West Papua. The method that has been used is the method of isolation and purification, bacterial selection through screening of probiotic candidate bacteria using MRS selective media and using NA media. Isolation technique by pouring method while prufication by streak method. The results of screening for probiotic bacteria candidates by using selective media, from 16 samples consisting of water samples and mud samples' obtained 11 positive samples, there were probiotic bacteria candidates with the bacterial morphological characteristics of each colony was almost similar.
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