Worldwide, ischaemic heart disease is the single most common cause of death and its frequency is increasing. However, in Europe, there has been an overall trend for a reduction in ischaemic heart disease mortality over the past three decades [1]. Ischaemic heart disease now accounts for almost 1.8 million annual deaths, or 20 % of all deaths in Europe, although with large variations between countries [2, 3].Basu et al. found that althrought IL-22 was secreted by various types of cells, Th22 (CD4 + IL – 22 + T) cells were the critical source of IL-22 during the later stages of inflammation, indicating that Th22 may be essential for controlling chronic inflammation. The effector cytokine of Th22 cells is IL-22, which belongs to the IL-10 cytokine family and binds to the heterodimeric receptor complex consisting of the IL-10 receptor (IL-10R) β chain and IL-22R.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.