In 14 patients with atopic dermatitis the superficial bacteria from unaffected skin were extracted with the scrub method, aerobically cultured, and analyzed qualitatively and quantitatively. For comparison, 12 healthy subjects served as control group. Staphylococcus aureus, as well as coagulase-negative staphylococci were significantly increased in patients with atopic dermatitis. It is assumed that special characteristics of the horny layer in atopic dermatitis favor the growth of aerobic bacteria. The qualitative biotyping and phage typing gave no support to the claim that special bacteria dominate the microbial flora of the skin of patients with atopic dermatitis.
As S. aureus is a relevant pathogen in atopic dermatitis, and gram-negative organisms, including Klebsiella and Proteus species, as well as S. aureus play a major role in the prophylactic skin care after leg eczema and leg ulcer treatment, TC appears to be suitable for maintenance therapy in these indications.
The findings described show that Candida species can be found in the feces of approximately half a population of nonselected test persons and in the mouths of approximately a third. Intestinal Candida colonization was found in most of these persons after one feces examination, and in practically all of them after a second examination. 10 d of therapy with 400 mg natamycin per day in sugar-coated tablet form and 40 mg natamycin in the form of tablets for sucking produced a negative fungus test for the feces in only 20% of the cases. Although a combination of this therapy with 3 x 10 mg butylscopolamine per day improved short-term results significantly, the long-term results were hardly influenced at all. Typifying results according to the Warnock method showed that we are dealing with recurrences in practically all cases and not with new infections. Minimal inhibition concentrations (MIC) of natamycin showed no marked changes as a consequence of the natamycin treatment.
Background: Literature reports indicate that phospholipid liposomes facilitate the accumulation of active agents in the infundibulum. Objective: The study hypothesis of an improved antibacterial efficacy of benzoyl peroxide (BPO) in phospholipid liposomes was tested in comparison with a commercial and a pharmacopoeial BPO preparation. Methods: The infundibular bacterial samples were obtained with the Permabond technique from 20 acne patients who had been treated with the test substances (vehicle-controlled) for 2 weeks twice per day in a single-blinded, comparative study on the upper back. Results: A significant antibacterial effect in the infundibula (Propionibacteria and Micrococcaceae, both: p < 0.001) for a BPO phospholipid liposome formulation could be demonstrated. In comparison to the other significantly efficacious BPO formulations which were also tested (commercial product and pharmacopoeial formulation), the BPO phospholipid liposome formulation showed a significantly greater antibacterial efficacy for Propionibacteria and Micrococcaceae (both: p < 0.01). Conclusion: A BPO formulation in phospholipid liposomes may represent an improvement of the conventional external BPO treatment of acne.
The surface skin lipids were estimated quantitatively (casual level and replacement sum) in 33 subjects using Brun’s osmic acid test and in 14 subjects using Schäfer’s and Kuhn-Bussius’s opaque glass test. Gravimetric estimation of surface lipids were also carried out on symmetrical areas of the upper back using Honsig’s method. Thin layer chromatography was used to analyse the composition of the surface lipids. The osmic acid test was found to be superior to the opaque glass test. The composition of the skin lipids had no significant effect upon either method.
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